Nicolas Lambert, Majdouline El Moussaoui, Jan Brijs, Paul Chauvet, Jonathan D Santoro, Sara Gil-Perotín, Sophie Servais, Evelyne Willems, Frédéric Baron, Yves Beguin, Julie Truong, Pierre Maquet, Olivier Bodart
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引用次数: 0
Abstract
In this multicenter retrospective study, we analyzed the EEG characteristics of 17 patients with possible CNS graft-versus-host disease (pCNS-GvHD). All EEGs were abnormal. Most (11/17 patients) showed background activity slowing. Sporadic epileptiform discharges were rare (2 patients) and observed only in chronic pCNS-GvHD. Sporatic non-epileptiform discharges, often generalized, frontally predominant, and triphasic, were common (15/17 patients). Two patients presented generalized rhythmic delta activity, one showed lateralized rhythmic delta activity, and one exhibited lateralized periodic discharges. Background activity slowing was statistically associated with higher one-year overall mortality (P=0.026). These findings suggest that EEG may serve as a prognostic tool in CNS-GvHD.
期刊介绍：
The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.
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