Spontaneous bone regeneration of post-enucleation defects of osteolytic lesions in the mandible: A digital three-dimensional morphometric analysis

Abstract

Background

Spontaneous bone regeneration after enucleation of osteolytic lesions in the mandible is crucial for healing bone defects. understanding when spontaneous bone regeneration suffices can help clinicians make informed decisions.

Purpose

This study aimed to assess the extent of spontaneous bone regeneration in post-enucleation mandibular osteolytic lesion cavities using a 3D digital approach. Secondary objectives included identifying factors like age, lesion size, and anatomical site that could influence regeneration.

Study design

The study included patients aged 18–65 years who underwent enucleation of an osteolytic mandibular lesion, with available pre-treatment and follow-up CBCT scans.

Main outcomes

The primary outcome was the percentage of regenerated bone volume ( %RBV), calculated using 3D-volumetric analysis. Secondary outcomes included age, gender, lesion volume and site, number of extracted teeth, bone-wall involvement, and follow-up.

Results

The study involved 20 patients, with a mean age of 40.1 ± 16.06 years. %RBV ranged from 32 % to 97 %, with a mean of 66.95 %. Significant predictors of regeneration included age, lesion site, and bone wall involvement.

Conclusions

Spontaneous bone regeneration can often achieve significant healing even in large defects; understanding the factors influencing this process can guide treatment strategies and improve clinical outcomes.