Microstructural changes in the caudate nucleus and hippocampus and their association with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study

IF 5.1 2区医学 Q1 NEUROSCIENCES

Neurobiology of Disease Pub Date : 2025-05-20 DOI:10.1016/j.nbd.2025.106964

Yiwen Chen , Meng Li , Jing Li , Yian Gao , Chaofan Sui , Na Wang , Xinyue Zhang , Yuanyuan Wang , Zhenyu Cheng , Pengcheng Liang , Lingfei Guo , Qihao Zhang , Changhu Liang

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引用次数: 0

Abstract

Background

Cerebral small vessel disease (CSVD) is associated with microstructural changes in subcortical gray matter linked to cognitive function. These changes may vary across different subregions. The aim of our study was to explore microstructural alterations in subcortical gray matter subregions associated with cognition in CSVD patients using magnetic resonance (MR) quantitative susceptibility mapping (QSM).

Methods

A total of 295 participants were included in the study, consisting of 112 healthy controls (HC), 85 with mild CSVD, and 98 with severe CSVD. All participants underwent MRI scans and cognitive function assessments. QSM images were segmented into 32 subcortical gray matter regions. Differences in susceptibility values across the three groups and their relationships with clinical and cognitive function were analyzed.

Results

After adjusting for potential confounders, the susceptibility values of the posterior part of the right hippocampus (pHIPr) (β = 1.209, P = 0.030) and the posterior part of the right caudate (pCAUr) (β = 4.373, P = 0.005) were positively correlated with CSVD severity. In the CSVD cohort, the mean susceptibility values of pCAUr were significantly associated with various cognitive functions. Furthermore, a simple mediation model demonstrated that the mean susceptibility value of pCAUr mediated the relationship between CSVD burden and SCWT score (indirect effect = 2.309, 95 % CI = 0.450–4.986, Pm = 21.5 %).

Conclusion

Our study revealed a relationship between microstructural changes of subcortical gray matter in CSVD patients and cognitive function and highlighted the potential of QSM in detecting brain microstructural alterations associated with cognition.

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脑小血管疾病尾状核和海马的微结构变化及其与认知功能的关系：一项定量易感性图谱研究

背景：脑小血管疾病（CSVD）与认知功能相关的皮层下灰质微结构改变有关。这些变化在不同的分区域可能有所不同。本研究的目的是利用磁共振（MR）定量易感图谱（QSM）探索CSVD患者与认知相关的皮层下灰质亚区微结构改变。方法共纳入295例受试者，其中健康对照112例，轻度CSVD 85例，重度CSVD 98例。所有参与者都接受了核磁共振扫描和认知功能评估。QSM图像被分割成32个皮层下灰质区域。分析三组患者的易感值差异及其与临床和认知功能的关系。结果校正潜在混杂因素后，右侧海马后部（pHIPr）（β = 1.209, P = 0.030）和右侧尾状核后部（pCAUr）（β = 4.373, P = 0.005）与CSVD严重程度呈正相关。在CSVD队列中，pCAUr的平均敏感性值与各种认知功能显著相关。此外，一个简单的中介模型表明，pCAUr的平均敏感性值介导了CSVD负荷与SCWT评分之间的关系（间接效应= 2.309,95% CI = 0.450-4.986, Pm = 21.5%）。结论本研究揭示了CSVD患者皮层下灰质微结构变化与认知功能之间的关系，并强调了QSM在检测认知相关脑微结构变化方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Disease 医学-神经科学

CiteScore

11.20

自引率

3.30%

发文量

270

审稿时长

76 days

期刊介绍： Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.