Numerical analysis of oscillating microbubbles coated with a lipid monolayer near a flexible tissue.

IF 1.7 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-05-21 DOI:10.1080/10255842.2025.2505651

Ramyar Doustikhah, Saeed Dinarvand, Pedram Tehrani, Mohammad Eftekhari Yazdi, Gholamreza Salehi

引用次数: 0

Abstract

Over the past two decades, ultrasound has advanced as a non-invasive drug delivery method. However, cavitation may cause cytoskeletal damage and cell death. This study numerically analyzes a compressible lipid-coated bubble near flexible tissue using Lattice Boltzmann and finite element methods. At 200 and 400 KPa ultrasound pressures, results show increased shear stress, boundary deformation, and bubble dynamics. The elastic boundary raises the bubble's resonance frequency. Shear stress rises from 0.09 to 0.61 KPa and 0.11 to 1.1 KPa during compression and expansion. A multi-pseudo-potential LBM improves cavitation modeling, revealing how proximity to cells intensifies pressure effects.

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柔性组织附近涂有脂质单层的振荡微泡的数值分析。

在过去的二十年里，超声波作为一种非侵入性的给药方法已经取得了进展。然而，空化可能导致细胞骨架损伤和细胞死亡。本文采用晶格玻尔兹曼和有限元方法对柔性组织附近的可压缩脂膜气泡进行了数值分析。在200和400 KPa的超声压力下，结果表明剪切应力、边界变形和气泡动力学增加。弹性边界提高了气泡的共振频率。在压缩和膨胀过程中，剪应力分别从0.09 ~ 0.61 KPa和0.11 ~ 1.1 KPa升高。多伪电位LBM改进了空化建模，揭示了接近细胞如何增强压力效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.