Investigation of antioxidant, antibacterial, anticancer and wound healing properties of eco-friendly synthesized copper oxide nanoparticles from Plumeria rubra leaf extract.
IF 3.5 3区 生物学Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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引用次数: 0
Abstract
Plants serve as a rich source of bioactive agents and coupling them with carriers using nanotechnology has recently become an effective therapeutic approach in pharmacognosy. Metal oxides, especially copper oxide (CuO), have been employed in synthesizing nanoparticles due to their efficient reducing properties. The purpose of this work was to examine the physicochemical, antioxidant, antibacterial, anticancer, and wound healing abilities of copper oxide nanoparticles (CuONPs) synthesized using Plumeria rubra leaf extract. FTIR, XRD, FESEM, EDX, AFM, and UV-vis spectroscopy were used to confirm the formation of CuONPs, and the results showed that they were spherical in shape and 35 nm in size. DPPH and nitric oxide antioxidant assays revealed that they possess effective free radical scavenging ability. CuONPs showed bactericidal activity against human pathogenic bacteria. The anticancer effect of CuONPs was assessed on the Neuro-2a (N2a) neuroblastoma cells. Both P. rubra leaf extract and CuONPs exhibited dose-dependent cytotoxicity with morphological distortions and apoptosis, along with a loss of membrane integrity. In vivo analysis of CuONPs for their wound healing ability in Wistar albino rats showed a better wound closure percentage compared to that of the control animals. Based on our findings, CuONPs may be applied as a potential therapeutic agent in developing treatments for a spectrum of various diseases.
期刊介绍：
Bioprocess and Biosystems Engineering provides an international peer-reviewed forum to facilitate the discussion between engineering and biological science to find efficient solutions in the development and improvement of bioprocesses. The aim of the journal is to focus more attention on the multidisciplinary approaches for integrative bioprocess design. Of special interest are the rational manipulation of biosystems through metabolic engineering techniques to provide new biocatalysts as well as the model based design of bioprocesses (up-stream processing, bioreactor operation and downstream processing) that will lead to new and sustainable production processes.
Contributions are targeted at new approaches for rational and evolutive design of cellular systems by taking into account the environment and constraints of technical production processes, integration of recombinant technology and process design, as well as new hybrid intersections such as bioinformatics and process systems engineering. Manuscripts concerning the design, simulation, experimental validation, control, and economic as well as ecological evaluation of novel processes using biosystems or parts thereof (e.g., enzymes, microorganisms, mammalian cells, plant cells, or tissue), their related products, or technical devices are also encouraged.
The Editors will consider papers for publication based on novelty, their impact on biotechnological production and their contribution to the advancement of bioprocess and biosystems engineering science. Submission of papers dealing with routine aspects of bioprocess engineering (e.g., routine application of established methodologies, and description of established equipment) are discouraged.
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