Frontiers and knowledge map of macrophage in wound healing: a scientometric and visualization analysis.

IF 2.2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-05-17 DOI:10.1016/j.jormas.2025.102410

Chongqing Yu, Chi Xu, Tao Wang, Jie Xu

{"title":"Frontiers and knowledge map of macrophage in wound healing: a scientometric and visualization analysis.","authors":"Chongqing Yu, Chi Xu, Tao Wang, Jie Xu","doi":"10.1016/j.jormas.2025.102410","DOIUrl":null,"url":null,"abstract":"Background: The skin is a protective barrier against environmental elements. Given its position as the body's outermost layer, the skin is vulnerable to injury, often leading to what we commonly refer to as wounds. Wound healing presents a substantial and intricate challenge in both clinical practice and scientific investigation. Among the key players in wound healing, macrophages hold a central role as primary inflammatory cells. Therefore, this study aims to portray the knowledge landscape in the realm of macrophages in wound healing through bibliometric analysis.Methods: Publications concerning macrophages in wound healing were comprehensively searched and selected from the Web of Science Core Collection(WOSCC) database.Results: A total of 1998 publications from 71 countries/regions, focusing on macrophages in wound healing, were identified and published between 1987 and 2023. China and the USA ranked as the top two contributors in this field. Leading institutions included Shanghai Jiaotong University, the University System of OHIO, the University of California System, the University of Illinois System, and the University of Manchester. Chen L emerged as the most prolific author with the highest number of citations, while Werner S ranked in the top one in the average citations. Among journals, the Journal of Investigative Dermatology had the most publications, while Wound Repair and Regeneration was the most cited. Noteworthy keywords in this area encompass antibacterial, nanoparticles, hydrogel, and antioxidant. The research focus has shifted from traditional mechanisms of wound healing to the advanced application of biomaterials. Emerging hotspots in research center around biomaterials, with keywords like 'hydrogel,' 'nanoparticles,' 'inflammation,' 'macrophage polarization,' and 'antibacterial' gaining prominence.Conclusion: Collectively, hydrogel stands out as a promising treatment approach for wound healing. This study offers an extensive overview of research on macrophages in wound healing from 1987 to 2023, utilizing bibliometric analysis, providing readers with a valuable reference to steer future research endeavors.","PeriodicalId":56038,"journal":{"name":"Journal of Stomatology Oral and Maxillofacial Surgery","volume":" ","pages":"102410"},"PeriodicalIF":2.2000,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Stomatology Oral and Maxillofacial Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jormas.2025.102410","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The skin is a protective barrier against environmental elements. Given its position as the body's outermost layer, the skin is vulnerable to injury, often leading to what we commonly refer to as wounds. Wound healing presents a substantial and intricate challenge in both clinical practice and scientific investigation. Among the key players in wound healing, macrophages hold a central role as primary inflammatory cells. Therefore, this study aims to portray the knowledge landscape in the realm of macrophages in wound healing through bibliometric analysis.

Methods: Publications concerning macrophages in wound healing were comprehensively searched and selected from the Web of Science Core Collection(WOSCC) database.

Results: A total of 1998 publications from 71 countries/regions, focusing on macrophages in wound healing, were identified and published between 1987 and 2023. China and the USA ranked as the top two contributors in this field. Leading institutions included Shanghai Jiaotong University, the University System of OHIO, the University of California System, the University of Illinois System, and the University of Manchester. Chen L emerged as the most prolific author with the highest number of citations, while Werner S ranked in the top one in the average citations. Among journals, the Journal of Investigative Dermatology had the most publications, while Wound Repair and Regeneration was the most cited. Noteworthy keywords in this area encompass antibacterial, nanoparticles, hydrogel, and antioxidant. The research focus has shifted from traditional mechanisms of wound healing to the advanced application of biomaterials. Emerging hotspots in research center around biomaterials, with keywords like 'hydrogel,' 'nanoparticles,' 'inflammation,' 'macrophage polarization,' and 'antibacterial' gaining prominence.

Conclusion: Collectively, hydrogel stands out as a promising treatment approach for wound healing. This study offers an extensive overview of research on macrophages in wound healing from 1987 to 2023, utilizing bibliometric analysis, providing readers with a valuable reference to steer future research endeavors.

查看原文本刊更多论文

巨噬细胞在伤口愈合中的前沿和知识图谱：科学计量学和可视化分析。

背景：皮肤是抵御环境因素的屏障。由于皮肤是身体的最外层，它很容易受伤，经常导致我们通常所说的伤口。伤口愈合在临床实践和科学研究中都提出了实质性和复杂的挑战。在伤口愈合的关键参与者中，巨噬细胞作为原发性炎症细胞发挥着核心作用。因此，本研究旨在通过文献计量学分析来描绘巨噬细胞在伤口愈合领域的知识景观。方法：从Web of Science Core Collection（WOSCC）数据库中全面检索和选择有关巨噬细胞在伤口愈合中的出版物。结果：1987年至2023年间，共发现并发表了来自71个国家/地区的1998篇关于巨噬细胞在伤口愈合中的研究。中国和美国是该领域贡献最大的两个国家。主要院校包括上海交通大学、俄亥俄大学系统、加州大学系统、伊利诺伊大学系统和曼彻斯特大学。陈l是被引用次数最多、最高产的作者，而Werner S在平均被引用次数上排名第一。在期刊中，《皮肤病学调查杂志》（Journal of Investigative Dermatology）的出版物最多，而《伤口修复与再生》（Wound Repair and Regeneration）的引用次数最多。该领域值得注意的关键词包括抗菌、纳米粒子、水凝胶和抗氧化剂。研究重点已从传统的伤口愈合机制转向生物材料的先进应用。新兴的研究热点围绕着生物材料，“水凝胶”、“纳米颗粒”、“炎症”、“巨噬细胞极化”和“抗菌”等关键词日益突出。结论：总的来说，水凝胶是一种很有前途的伤口愈合治疗方法。本研究利用文献计量学分析，对1987年至2023年巨噬细胞在伤口愈合中的研究进行了广泛的概述，为读者指导未来的研究工作提供了有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.