Biotransformation of limonene: pathways, biocatalysts, and applications

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-05-10 DOI:10.1016/j.fbio.2025.106812

Lulu Zhang , Wanying Wang , Zixuan Wang , Weimin Song , Haoliang Li , Jinchu Yang , Zhenzhen Huang , Gang Fan , Jingnan Ren , Yujiao Cheng , Aiqun Yu , Jian Feng

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Abstract

Biotransformation of limonene is considered as a promising approach for the production of bioactive compounds. These compounds with excellent aroma characteristics and health benefits, such as perillyl alcohol, carvone, and α-terpineol, have great market potential in food, fragrance, cosmetics, pharmaceutical, and agricultural industries. Here, we summarize the products and pathways of limonene biotransformation and highlight the biocatalysts involved in this bioprocess. Numerous microorganisms (e.g., fungi, bacteria and microalgae), enzymes isolated from these microorganisms (e.g., cytochrome P450 enzyme, dehydrogenase, epoxide hydrolase, etc), as well as recombinant cells expressing these enzymes, can degrade and transform limonene into valuable products. Additionally, the extraction and purification of these products from fermentation broth, and their industrial applications are introduced. Finally, the future prospects of limonene biotransformation are discussed.

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柠檬烯的生物转化：途径、生物催化剂和应用

柠檬烯的生物转化被认为是一种很有前途的生产生物活性化合物的方法。紫苏醇、香芹酮、α-松油醇等具有优良香气特性和保健功效的化合物，在食品、香料、化妆品、医药、农业等领域具有巨大的市场潜力。本文综述了柠檬烯生物转化的产物和途径，并重点介绍了参与这一生物过程的生物催化剂。许多微生物（如真菌、细菌和微藻）、从这些微生物中分离出的酶（如细胞色素P450酶、脱氢酶、环氧化物水解酶等）以及表达这些酶的重组细胞都可以降解柠檬烯并将其转化为有价值的产物。此外，还介绍了从发酵液中提取、纯化这些产品及其工业应用。最后，对柠檬烯生物转化的发展前景进行了展望。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.