Recent innovations in Grifola frondosa polysaccharides: production, properties, and their biological activity

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-05-10 DOI:10.1016/j.fbio.2025.106765

Umar Zeb , Tariq Aziz , Wen-Jing Sun , Abdul Haleem , Guo-Qiang Guan , Li-Juan Meng , Lei Sun , Feng-Jie Cui

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引用次数: 0

Abstract

Grifola frondosa is a highly valuable edible and medicinal fungus with significant health benefits. In traditional Chinese medicine, has been extensively utilized for its therapeutic properties, playing a vital role in treating various diseases related to immune modulation and inflammation. Polysaccharides are the main active compound in G. frondosa, and their biological activities are closely related to their composition. The Grifola frondosa polysaccharides (GFPs) interact with key immune receptors such as Toll-like receptors and Dectin-1, which activate macrophages, natural killer cells, and dendritic cells. This interaction enhances the immune system's capacity to mount effective responses against infections and malignancies. These polysaccharides control glucose metabolism and regulate insulin sensitivity, indicating their potential for managing and preventing metabolic disorders like diabetes. Although the preclinical studies are promising, further research is essential to standardize extraction techniques, conform clinical efficacy, and clarify the mechanism of health benefits. This review provides a comprehensive overview of recent advances in the production, properties, structural characteristics, and biological activities of GFPs. It highlights their therapeutic potential and promotes further research to support their development and application in functional foods, nutraceuticals, and pharmaceutical formulation.

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灰树花多糖的新进展：生产、性质及其生物活性

灰树花（Grifola frondosa）是一种非常有价值的食用和药用真菌，具有重要的保健作用。在中医中，由于其治疗特性而被广泛使用，在治疗与免疫调节和炎症有关的各种疾病中起着至关重要的作用。多糖是灰树花中的主要活性物质，其生物活性与其组成密切相关。灰树花多糖（Grifola frondosa polysaccharides, gfp）与toll样受体和Dectin-1等关键免疫受体相互作用，激活巨噬细胞、自然杀伤细胞和树突状细胞。这种相互作用增强了免疫系统对感染和恶性肿瘤的有效反应能力。这些多糖控制葡萄糖代谢和调节胰岛素敏感性，表明它们有可能控制和预防代谢紊乱，如糖尿病。虽然临床前研究前景广阔，但为了规范提取技术，符合临床疗效，明确健康益处机制，还需要进一步的研究。本文就gfp的制备、性质、结构特征和生物活性等方面的研究进展进行了综述。它强调了它们的治疗潜力，并促进了进一步的研究，以支持它们在功能食品、营养保健品和药物配方中的开发和应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.