Comparative study of microneedle insertion across different skin models.

IF 1.7 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-04-30 DOI:10.1080/10255842.2025.2495300

Xuan He, Xue Sui, Yongchao Liu, Rui Zhou, Shouying Du

引用次数: 0

Abstract

Microneedles (MNs) enhance drug delivery by painlessly penetrating the stratum corneum, with hardness being crucial for safe insertion. While human/animal skins and synthetic materials are used to test MNs, their variability affects results. Finite element methods (FEM) simulate insertion, but skin model complexity and software limitations cause inconsistencies. This study employs FEM to compare MN performance across skun models under uniform conditions. Results reveal small volume change differences during insertion and rank penetration ease for human/animal models, aiding skin model selection and species-specific MN design optimization.

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不同皮肤模型微针插入的比较研究。

微针（MNs）通过无痛穿透角质层来增强药物输送，硬度对安全插入至关重要。虽然人类/动物皮肤和合成材料被用来测试纳米粒子，但它们的可变性会影响结果。有限元方法可以模拟插入，但蒙皮模型的复杂性和软件的限制导致了不一致性。本研究采用有限元法比较了均匀条件下不同skun模型MN的性能。结果表明，人体/动物模型在插入和rank穿透过程中体积变化差异较小，有助于皮肤模型选择和物种特异性MN设计优化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.