Safety and efficacy of extracellular vesicles in individuals with cancer; A systematic review.

IF 2.2 4区工程技术 Q3 PHARMACOLOGY & PHARMACY

Bioimpacts Pub Date : 2024-09-29 eCollection Date: 2025-01-01 DOI:10.34172/bi.30501

Hila Asham, Negin Jafari, Elham Mohamadrezapour, Hossein Bannazadeh Baghi, Hosein Eslami, Taher Entezari-Maleki

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引用次数: 0

Abstract

Introduction: Extracellular vesicles (EVs) are crucial in intercellular signaling pathways. Since cancer has had a significant impact on global health as the second leading cause of death, this study aimed to systematically review the literature on the efficacy and safety of EVs in this setting.

Methods: A systematic literature review was performed on MEDLINE, Embase, the Cochrane Library, and ClinicalTrials.gov from database inception until August 10th, 2023. Based on PICOS, the inclusion criteria were: individuals with cancer treated with EVs compared to control among clinical studies.

Results: EVs administered to 46 individuals with cancer. Most studies revealed significant clinical benefits after treatment. Results also demonstrated that EVs are safe without major adverse events (AEs).

Conclusion: The use of EVs may provide potential therapeutic benefits for treating cancer. Further, well-designed randomized clinical trials (RCTs) are needed to provide robust evidence for supporting the clinical use of EVs in this setting.

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细胞外囊泡治疗癌症患者的安全性和有效性系统回顾。

细胞外囊泡（EVs）在细胞间信号通路中起着至关重要的作用。由于癌症作为第二大死亡原因对全球健康产生了重大影响，本研究旨在系统地回顾关于电动汽车在这种情况下的有效性和安全性的文献。方法：系统回顾MEDLINE、Embase、Cochrane Library和ClinicalTrials.gov从数据库建立到2023年8月10日的文献。基于PICOS，纳入标准是：与临床研究中的对照组相比，接受ev治疗的癌症患者。结果：46例癌症患者接受了ev治疗。大多数研究显示治疗后显著的临床益处。结果还表明，电动汽车是安全的，没有重大不良事件（ae）。结论：EVs在肿瘤治疗中具有潜在的疗效。此外，需要精心设计的随机临床试验（rct），为支持电动汽车在这种情况下的临床使用提供强有力的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioimpacts Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.80

自引率

7.70%

发文量

审稿时长

5 weeks

期刊介绍： BioImpacts (BI) is a peer-reviewed multidisciplinary international journal, covering original research articles, reviews, commentaries, hypotheses, methodologies, and visions/reflections dealing with all aspects of biological and biomedical researches at molecular, cellular, functional and translational dimensions.