Application of non-invasive brain stimulation combined with functional magnetic resonance imaging in post-stroke motor function rehabilitation.

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-05-06 DOI:10.1016/j.jneumeth.2025.110470

Xiaoli Zou, Jiaju Zhu, Song Hu, Zhen Hou, Guodong Ma

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引用次数: 0

Abstract

Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising non-invasive brain stimulation (NIBS) system for post-stroke motor rehabilitation. However, its underlying mechanisms are still not well understood.

New method: In this research, 170 post-stroke patients with motor impairments were randomly divided into an rTMS intervention group (n = 85) and a control group (n = 85). Along with routine motor rehabilitation exercises, the rTMS group received 30minutes of 5Hz rTMS over the left Dorsolateral Prefrontal Cortex (DPC) three times a week for 30 days. Sham rTMS treatment can be allocated to the control group. Resting-state functional magnetic resonance imaging (rs-fMRI) was used to evaluate brain activity and functional connectivity (FC) in motor-related areas.

Results: Both the intervention and control groups showed significant motor function improvements, but the rTMS group had more substantial gains. In the intervention group, FCA values in motor regions such as the primary motor cortex (PMC) and Precentral Gyrus (PCG) improved. There was also an increase in FC between the DPC and motor areas.

Comparison with existing methods: Unlike some previous studies that may have focused only on motor function improvement without in-depth exploration of brain activity and connectivity changes, this study used rs-fMRI to comprehensively analyze the cerebral functional alterations induced by rTMS, providing a more detailed understanding of the underlying mechanisms of rTMS in post-stroke rehabilitation.

Conclusions: The findings suggest that rTMS promotes motor recovery in post-stroke patients by modulating brain activity and connectivity within motor networks.

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无创脑刺激联合功能磁共振成像在脑卒中后运动功能康复中的应用。

背景：重复经颅磁刺激（rTMS）是一种很有前途的无创脑刺激（NIBS）系统，用于脑卒中后运动康复。然而，其潜在机制仍未得到很好的理解。新方法：本研究将170例脑卒中后运动障碍患者随机分为rTMS干预组（n = 85）和对照组（n = 85）。在常规运动康复训练的同时，rTMS组在左背外侧前额叶皮层（DPC）上接受30分钟的5Hz rTMS，每周3次，持续30天。假性rTMS治疗可分配给对照组。静息状态功能磁共振成像（rs-fMRI）评估脑活动和运动相关区域的功能连通性（FC）。结果：干预组和对照组均表现出明显的运动功能改善，但rTMS组有更明显的改善。在干预组，运动区域如初级运动皮层（PMC）和中央前回（PCG）的FCA值有所改善。DPC和运动区之间的FC也有所增加。与现有方法的比较：与以往一些研究可能只关注运动功能的改善，而没有深入探索大脑活动和连通性的变化不同，本研究利用rs-fMRI全面分析了rTMS诱导的脑功能改变，更详细地了解了rTMS在脑卒中后康复中的潜在机制。结论：研究结果表明，rTMS通过调节大脑活动和运动网络内的连通性来促进中风后患者的运动恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.