Association between neutrophil percentage-to-albumin ratio and breast cancer in adult women in the US: findings from the NHANES.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1533636

Huikai Liang, Kelun Pan, Jiayi Wang, Jianqing Lin

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引用次数: 0

Abstract

Background: An increasing number of studies suggests an association between systemic inflammation, nutritional status, and cancer. However, the relationship between the prevalence of breast cancer (BC) and the neutrophil-percentage-to-albumin ratio (NPAR), a recently identified biomarker of inflammation, is not well established. Therefore, this study aims to investigate the relationship between BC risk and the NPAR.

Methods: This study included 18,726 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2018. The NPAR was used to assess inflammation and nutritional status. Statistical methods such as multivariate logistic regression, subgroup analysis, and restricted cubic spline (RCS) analysis were conducted to investigate the influence of NPAR on the prevalence of BC. In addition, propensity score matching was employed to further validate the findings.

Results: The logistic regression results showed that the prevalence of breast cancer is significantly associated with the NPAR (OR = 1.05; 95% CI = 1.02-1.09, p = 0.003). In comparison to participants in the lowest quartile, Q1, the prevalence of breast cancer increased by 5% for those in Q2 (p = 0.745), 3% for those in Q3 (p = 0.032), and 38% for those in Q4 (p = 0.018) with a higher NPAR. In addition, subgroup and RCS analyses showed that the NPAR and BC prevalence were positively correlated. Furthermore, a significant association was observed between the NPAR and marital status. The significance of traits was assessed using mean decrease accuracy (MDA) and mean decrease impurity (MDI). These measures of random forest modeling showed that NPAR is one of the major factors affecting the prevalence of BC. Furthermore, linear analysis demonstrated a correlation between a high NPAR and increased total testosterone and sex hormone-binding globulin (SHBG) levels.

Conclusion: A significant association was observed between a high NPAR and a higher prevalence of breast cancer, which could be attributable to sex hormone levels. This finding suggests that the NPAR may serve as a biomarker for BC in adult women in the US.

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美国成年女性中性粒细胞百分比与白蛋白比率与乳腺癌之间的关系：来自NHANES的研究结果。

背景：越来越多的研究表明全身性炎症、营养状况和癌症之间存在关联。然而，乳腺癌患病率（BC）与中性粒细胞百分比与白蛋白比率（NPAR）之间的关系（NPAR是最近发现的炎症生物标志物）尚未得到很好的确定。因此，本研究旨在探讨BC风险与NPAR之间的关系。方法：本研究纳入了2001年至2018年间进行的国家健康与营养检查调查（NHANES）的18726名参与者。NPAR用于评估炎症和营养状况。采用多元logistic回归、亚组分析、限制性三次样条（RCS）分析等统计方法探讨NPAR对BC患病率的影响。此外，采用倾向得分匹配来进一步验证研究结果。结果：logistic回归结果显示，乳腺癌患病率与NPAR显著相关(OR = 1.05；95% CI = 1.02-1.09,p = 0.003)。与最低四分位数Q1的参与者相比，NPAR较高的Q2的乳腺癌患病率增加了5% (p = 0.745)，Q3的患病率增加了3% (p = 0.032)，Q4的患病率增加了38% （p = 0.018）。此外，亚组和RCS分析显示NPAR与BC患病率呈正相关。此外，NPAR与婚姻状况之间存在显著相关。采用平均减少精度（MDA）和平均减少杂质（MDI）评价各性状的显著性。这些随机森林模型的测量结果表明，NPAR是影响BC患病率的主要因素之一。此外，线性分析表明，高NPAR与总睾酮和性激素结合球蛋白（SHBG）水平升高之间存在相关性。结论：观察到高NPAR与高乳腺癌患病率之间存在显著关联，这可能归因于性激素水平。这一发现提示NPAR可以作为美国成年女性BC的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.