Chlorogenic acid and intestinal health: mechanistic insights and therapeutic applications.

IF 5.1 1区农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Food & Function Pub Date : 2025-05-13 DOI:10.1039/d5fo00853k

Jinzhao Xu, Xiao Zhao, Shuo Yang, Mengqi Tang, Runan Zhao, Shumeng Hu

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引用次数: 0

Abstract

Chlorogenic acid (CGA), a polyphenolic compound found in various plant species, has shown considerable potential in the treatment and management of several diseases due to its potent bioactive properties. Increasing evidence indicates that CGA exerts significant antioxidant, anti-inflammatory, and immunomodulatory effects by modulating key signaling pathways, including MAPK, PTEN/Akt, STAT3, and NF-κB/NLRP3. Furthermore, CGA enhances intestinal barrier function and positively influences the gut microbiota composition, making it a promising natural therapeutic agent for conditions such as inflammatory bowel disease, irritable bowel syndrome, and colorectal cancer. This review provides a comprehensive summary of the most recent research on CGA's role in managing intestinal disorders. It first discusses CGA's chemical structure and pharmacokinetics (including absorption and metabolism), followed by an in-depth analysis of the mechanisms through which CGA mediates its therapeutic effects. These insights aim to advance our understanding of CGA's therapeutic potential in treating intestinal diseases.

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绿原酸与肠道健康：机理见解和治疗应用。

绿原酸（Chlorogenic acid， CGA）是一种存在于多种植物中的多酚类化合物，由于其强大的生物活性，在多种疾病的治疗和管理中显示出相当大的潜力。越来越多的证据表明，CGA通过调节MAPK、PTEN/Akt、STAT3和NF-κB/NLRP3等关键信号通路发挥显著的抗氧化、抗炎和免疫调节作用。此外，CGA增强肠道屏障功能，积极影响肠道微生物群组成，使其成为炎症性肠病、肠易激综合征和结直肠癌等疾病的有希望的天然治疗剂。本文综述了CGA在治疗肠道疾病中的作用的最新研究。首先讨论了CGA的化学结构和药代动力学（包括吸收和代谢），然后深入分析了CGA介导其治疗作用的机制。这些见解旨在促进我们对CGA治疗肠道疾病的治疗潜力的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY

CiteScore

10.10

自引率

6.60%

发文量

957

审稿时长

1.8 months

期刊介绍： Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.