The Pathogenic Fungal Genus Corynespora: A Prolific Source of Bioactive Secondary Metabolites.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-05-23 Epub Date: 2025-04-24 DOI:10.1021/acs.jnatprod.5c00145

Yi Hua, Gangao Hu, Titi Ying, Jiangwei Pan, Zhenyi Zhou, Cuixian Zhang, Hong Wang, Bin Wei

引用次数: 0

Abstract

In this perspective, we examine the chemical structures and biological activities of 55 secondary metabolites isolated from the pathogenic fungal genus Corynespora. Over 20% of these compounds demonstrate bioactivities, including antibacterial, anticancer, enzyme inhibition, and others. Bioinformatic analysis reveals that Corynespora possesses a high potential for encoding PKS-I and NRPS natural products, including many clade-specific metabolites, and only 2.1% of biosynthetic gene cluster families are associated with known secondary metabolites. This study underscores the significant, unexplored potential of Corynespora strains for synthesizing novel secondary metabolites, providing valuable insights into the targeted discovery and biosynthesis of novel natural products from this genus.

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致病真菌Corynespora属：生物活性次生代谢物的多产来源。

从这个角度来看，我们研究了从致病真菌属Corynespora中分离的55种次级代谢物的化学结构和生物活性。这些化合物中超过20%显示出生物活性，包括抗菌、抗癌、酶抑制等。生物信息学分析表明，Corynespora具有很高的编码PKS-I和NRPS天然产物的潜力，包括许多枝特异性代谢物，并且只有2.1%的生物合成基因簇家族与已知的次生代谢物相关。这项研究强调了Corynespora菌株在合成新的次级代谢物方面的重要潜力，为该属的新型天然产物的靶向发现和生物合成提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.