Assessing ultrasonic and optical flow velocimetry in a millifluidic device using oil-in-water emulsions as blood mimicking fluid

IF 2.8 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Micro and Nano Engineering Pub Date : 2025-05-08 DOI:10.1016/j.mne.2025.100298

Estelle Lu , Williams Flores Cisternas , Héloïse Uhl , Alexandre Chargueraud , Quentin Grimal , Guillaume Renaud , Jean-Gabriel Minonzio , Jacques Fattaccioli

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Abstract

Blood-mimicking fluids (BMFs) play a critical role in ultrasonic imaging and Doppler flow studies by replicating the physical and acoustic properties of blood. This study introduces a novel soybean oil-in-water emulsion as a BMF with particle size akin to red blood cells. Using a millifluidic device, we cross-validated flow profiles through both Doppler velocimetry and optical particle tracking, demonstrating compatibility with theoretical Poiseuille flow models. The millifluidic chip, fabricated via stereolithography, provided an optimized platform for dual optical and ultrasonic assessments. Results showed strong agreement between the two methods across a range of flow rates, affirming the suitability of the emulsion for velocimetry applications. Furthermore, the acoustic properties of soybean oil droplets support their potential as an echogenic and stable alternative to conventional BMFs.

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利用水包油乳剂作为模拟血液的液体，在微流体装置中评估超声和光流速测量

血液模拟液（BMFs）通过复制血液的物理和声学特性，在超声成像和多普勒血流研究中发挥着关键作用。本研究介绍了一种新型的大豆油水包乳剂，其颗粒大小类似于红细胞。使用微流体装置，我们通过多普勒测速和光学粒子跟踪交叉验证了流动剖面，证明了与理论泊泽维尔流动模型的兼容性。通过立体光刻制造的微流控芯片为双光学和超声评估提供了优化的平台。结果表明，两种方法在一定的流速范围内具有很强的一致性，证实了乳液在测速应用中的适用性。此外，大豆油液滴的声学特性支持它们作为传统生物燃料的回声和稳定替代品的潜力。

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