Optimizing portable gas sensor system for hepatocellular carcinoma detection via volatile organic compounds analysis

IF 5.2 2区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Measurement Pub Date : 2025-05-08 DOI:10.1016/j.measurement.2025.117802

Charusluk Viphavakit , Thanikan Sukaram , Soe Thiha Maung , Rungsun Rerknimitr , Roongruedee Chaiteerakij

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Abstract

The analysis of volatile organic compounds (VOCs) in exhaled breath is a promising method for the early detection of hepatocellular carcinoma (HCC). However, the current technology suffers from a lack of portability, rendering it unsuitable for field-based screening applications. This study designed a compact sensor system operated in real-time, as detecting the 5 HCC biomarkers simultaneously was vital for accurate diagnosis due to cross-biomarkers for various diseases. The results showed that the optimized gas sensor system included injection volume of 3.0 mL, heating the Tedlar bag to 80 °C, and applying a 1-minute nitrogen purge, which achieved a rapid response time. The proposed gas sensor system has demonstrated excellent performance, with a concentration range of 10–1,000 ppb and strong linearity (R² > 0.85). This portable analyzer is easy to use, delivers rapid results, and is suitable for point-of-care testing. Further studies are warranted to validate its performance with human breath samples before its implementation in clinical practice.

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通过挥发性有机化合物分析优化便携式肝细胞癌检测气体传感器系统

呼气中挥发性有机化合物（VOCs）的分析是一种很有前途的肝细胞癌（HCC）早期检测方法。然而，目前的技术缺乏可移植性，使其不适合现场筛选应用。本研究设计了一个紧凑的实时传感器系统，因为同时检测5种HCC生物标志物对于准确诊断至关重要，因为多种疾病的生物标志物交叉。结果表明，优化后的气体传感器系统进样量为3.0 mL，将Tedlar袋加热至80℃，氮气吹扫1分钟，响应时间较短。所提出的气体传感器系统具有优异的性能，浓度范围为10-1,000 ppb，线性度强(R2 >；0.85)。这种便携式分析仪易于使用，提供快速结果，适用于即时检测。在临床应用之前，需要进一步的研究来验证其在人类呼吸样本中的性能。

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来源期刊

Measurement 工程技术-工程：综合

CiteScore

10.20

自引率

12.50%

发文量

1589

审稿时长

12.1 months

期刊介绍： Contributions are invited on novel achievements in all fields of measurement and instrumentation science and technology. Authors are encouraged to submit novel material, whose ultimate goal is an advancement in the state of the art of: measurement and metrology fundamentals, sensors, measurement instruments, measurement and estimation techniques, measurement data processing and fusion algorithms, evaluation procedures and methodologies for plants and industrial processes, performance analysis of systems, processes and algorithms, mathematical models for measurement-oriented purposes, distributed measurement systems in a connected world.