{"title":"Nucleation Control and Separation of Ethyl Maltol Polymorphs II and III from Water-Ethanol Solvent Mixtures","authors":"Anitha Thirumalaisamy, Srinivasan Karuppannan","doi":"10.1002/crat.202400274","DOIUrl":null,"url":null,"abstract":"<p>Nucleation control and separation of ethyl maltol polymorphs Form-II and Form-III from mixed water (W) and ethanol (E) solutions with nine different mixing ratios, ranging from 90W:10E to 10W:90E, is reported for the first time using conventional slow evaporation crystallization method. Solutions with compositions of 90W:10E to 60W:40E induced Form-II, while the remaining five compositions resulted in the nucleation of Form-III. Solubility, refractive index, and pH are determined for these solutions. Form-II nucleated with prismatic-like morphology whereas Form-III exhibited platy-like morphology, as observed through in situ optical microscopy. Structural confirmation, thermal behavior, and possible polymorphic phase transformation are analyzed using powder X-ray diffraction and differential scanning calorimetry.</p>","PeriodicalId":48935,"journal":{"name":"Crystal Research and Technology","volume":"60 5","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crystal Research and Technology","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/crat.202400274","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
Abstract
Nucleation control and separation of ethyl maltol polymorphs Form-II and Form-III from mixed water (W) and ethanol (E) solutions with nine different mixing ratios, ranging from 90W:10E to 10W:90E, is reported for the first time using conventional slow evaporation crystallization method. Solutions with compositions of 90W:10E to 60W:40E induced Form-II, while the remaining five compositions resulted in the nucleation of Form-III. Solubility, refractive index, and pH are determined for these solutions. Form-II nucleated with prismatic-like morphology whereas Form-III exhibited platy-like morphology, as observed through in situ optical microscopy. Structural confirmation, thermal behavior, and possible polymorphic phase transformation are analyzed using powder X-ray diffraction and differential scanning calorimetry.
期刊介绍：
The journal Crystal Research and Technology is a pure online Journal (since 2012).
Crystal Research and Technology is an international journal examining all aspects of research within experimental, industrial, and theoretical crystallography. The journal covers the relevant aspects of
-crystal growth techniques and phenomena (including bulk growth, thin films)
-modern crystalline materials (e.g. smart materials, nanocrystals, quasicrystals, liquid crystals)
-industrial crystallisation
-application of crystals in materials science, electronics, data storage, and optics
-experimental, simulation and theoretical studies of the structural properties of crystals
-crystallographic computing
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