Cortical response to proprioceptive stimulation in primary orthostatic tremor – a magnetoencephalography study

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.04.002

Karolina af Edholm , Mikkel C. Vinding , Christoph Pfeiffer , Anders Svenningsson , Erik Fransén , Mathias Sundgren , Henrik Sjöström , Niklas Edvall , Daniel Lundqvist , Josefine Waldthaler

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引用次数: 0

Abstract

Objective

Patients with primary orthostatic tremor (OT) are affected by a strong feeling of instability. Our aim was to investigate whether cortical response to proprioceptive information is altered in OT compared with healthy control subjects (HC) using magnetoencephalography (MEG).

Methods

Fifteen OT patients and 15 HCs were examined using whole-head MEG. Proprioceptive stimulation was evoked by passive movements of the right index finger and right foot. Time-frequency responses were extracted in the frequency range of 8–30 Hz. The MEG sensor with the highest amplitude change time-locked to the proprioceptive stimulus was used to calculate the amplitude of event-related desynchronization (ERD) and subsequent event-related re-synchronization (ERS).

Results

Finger stimulation induced reliable ERD and ERS, as expected, in both OT patients and HC. Foot stimulation induced weaker ERS in both groups. Cluster-based permutation tests did not reveal any significant differences between the OT and HC groups.

Discussion

We did not find evidence supporting a generally altered cortical response to proprioceptive stimulation in patients with OT.

Significance

This is the first study on proprioceptive cortical processing in OT. The results do not support the interpretation that the characteristic intense feeling of instability in OT is linked to altered cortical response to proprioceptive information.

查看原文本刊更多论文

原发性直立性震颤的皮层对本体感觉刺激的反应-脑磁图研究

目的原发性直立性震颤（OT）患者有强烈的不稳定感。我们的目的是利用脑磁图（MEG）研究与健康对照组（HC）相比，OT患者对本体感觉信息的皮质反应是否发生了改变。方法对15例OT患者和15例hc患者进行全头部MEG检查。右食指和右脚被动运动可诱发本体感觉刺激。提取8 ~ 30 Hz频率范围内的时频响应。利用本体感觉刺激时振幅变化最大的MEG传感器计算事件相关去同步（ERD）和随后的事件相关再同步（ERS）的振幅。结果如预期的那样，手指刺激在OT患者和HC患者中均可诱导可靠的ERD和ERS。两组足部刺激均引起较弱的ERS。基于簇的排列测试没有发现OT组和HC组之间的任何显著差异。讨论：我们没有发现证据支持OT患者对本体感觉刺激的皮层反应普遍改变。意义本研究首次对OT中本体感觉皮层加工进行了研究。结果不支持OT中特征性的强烈不稳定感与皮层对本体感觉信息的反应改变有关的解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.