{"title":"Polycyclic aromatic hydrocarbon-aryl hydrocarbon receptor signaling regulates chronic inflammation in lung-gut axis","authors":"Tzu-Yu Cheng , Ching-Shan Luo , Po-Hao Feng , Kuan-Yuan Chen , Chih-Cheng Chang , Nguyen Van Hiep , Yueh-His Chen , Yun-Kai Yeh , Sheng-Ming Wu","doi":"10.1016/j.taap.2025.117359","DOIUrl":null,"url":null,"abstract":"<div><div>Polycyclic aromatic hydrocarbons (PAHs) are broadly identified in environmental pollutants and also formed during the heat processing of meat, including grilling, roasting, smoking, and frying, particularly at high temperatures. Besides, the PAHs influence inflammatory response through activation of aryl hydrocarbon receptor (AhR) signaling. Recently, the role of the PAHs/AhR axis in inflammatory diseases has attracted major attention in the regulation of lung function, gut barrier function, and systemic inflammation. Many experiments have been conducted to determine the role of the PAHs/AhR/cytochrome P450 1A1 signaling activation on elevation of inflammation in the lung–gut axis. In contrast, several dietary AhR ligands can improve inflammatory function by modulating the AhR signaling, thereby strengthening the intestinal barrier. This review includes the pivotal roles of xenobiotic and diet-derived AhR ligands in the regulation of chronic lung diseases and systemic inflammation and their relevance in the lung–gut axis.</div></div>","PeriodicalId":23174,"journal":{"name":"Toxicology and applied pharmacology","volume":"500 ","pages":"Article 117359"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology and applied pharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0041008X25001358","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are broadly identified in environmental pollutants and also formed during the heat processing of meat, including grilling, roasting, smoking, and frying, particularly at high temperatures. Besides, the PAHs influence inflammatory response through activation of aryl hydrocarbon receptor (AhR) signaling. Recently, the role of the PAHs/AhR axis in inflammatory diseases has attracted major attention in the regulation of lung function, gut barrier function, and systemic inflammation. Many experiments have been conducted to determine the role of the PAHs/AhR/cytochrome P450 1A1 signaling activation on elevation of inflammation in the lung–gut axis. In contrast, several dietary AhR ligands can improve inflammatory function by modulating the AhR signaling, thereby strengthening the intestinal barrier. This review includes the pivotal roles of xenobiotic and diet-derived AhR ligands in the regulation of chronic lung diseases and systemic inflammation and their relevance in the lung–gut axis.
期刊介绍:
Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products.
Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged.
Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.