Sensitive and selective simultaneous detection of ampicillin and chloramphenicol in foods with a SERS-activated molecularly imprinted capillary sensor

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-05-02 DOI:10.1016/j.foodchem.2025.144618

Sisi Tang, Ruili Li, Shuting Huang, Qi Liu, Xiaoqing Chen

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引用次数: 0

Abstract

The specific identification and effective surface-enhanced Raman scattering (SERS) detection of multiple antibiotic residues in food samples remain challenging due to the interference of complex matrices and the low concentrations of the target analytes. Herein, we develop a novel sensor (SERS-CP-MI) that integrates SERS with molecular imprinting technology for sensitive and selective simultaneous detection of ampicillin (AMP) and chloramphenicol (CAP). The SERS-activated capillary (SERS-CP) utilizes capillary as carriers for plasmonic nanoparticles (Ag NPs) serving as recognition unit, where the modification of Ag NPs on the inner wall of the capillaries significantly enhances sensitivity. Meanwhile, the dual-template imprinted polymer (TMIP) was synthesized as capture unit through bulk polymerization and surface imprinting, forming specific cavities for simultaneous detection of AMP and CAP. The proposed method was successfully applied to chicken and milk samples, demonstrating that the SERS-CP-MI sensor is a reliable and effective tool for detecting antibiotic residues in food samples.

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用sers激活的分子印迹毛细管传感器灵敏、选择性地同时检测食品中氨苄西林和氯霉素

由于复杂基质和低浓度目标分析物的干扰，食品样品中多种抗生素残留的特异性鉴定和有效的表面增强拉曼散射（SERS）检测仍然具有挑战性。在此，我们开发了一种新型传感器（SERS- cp - mi），该传感器将SERS与分子印迹技术相结合，用于敏感和选择性地同时检测氨苄西林（AMP）和氯霉素（CAP）。sers活化毛细管（SERS-CP）利用毛细管作为载体，等离子体纳米粒子（Ag NPs）作为识别单元，其中Ag NPs在毛细管内壁的修饰显著提高了灵敏度。同时，通过本体聚合和表面印迹合成双模板印迹聚合物（TMIP）作为捕获单元，形成可同时检测AMP和CAP的特定空腔。该方法成功应用于鸡肉和牛奶样品中，验证了SERS-CP-MI传感器是检测食品样品中抗生素残留的可靠有效工具。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.