Metal-organic framework UiO-66-NH2 functionalized polydopamine-modified magnetic multi-walled carbon nanotubes for convenient magnetic solid-phase extraction of sixteen quinolones

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-05-02 DOI:10.1016/j.foodchem.2025.144604

Lin Lv, Hongmei Liu, Lei Wang, Sikai Wang, Yue Li, Guoqi Zhang, Yan Zhao

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Abstract

In this study, an innovative magnetic solid-phase extraction adsorbent based on metal-organic framework UiO-66-NH₂ functionalized polydopamine-modified magnetic multi-walled carbon nanotubes (Fe₃O₄@MWCNTs@PDA@UiO-66-NH₂) was developed for the selective extraction of trace amounts of quinolones (QNs) from milk and honey. Under optimal conditions, when coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), the developed approach demonstrated excellent linearity in the concentration range of 0.1–100 μg kg⁻¹ (R² ≥ 0.9916). The recoveries for sixteen QNs ranged from 72.4 % to 108.9 %, with relative standard deviations less than 9.40 %. The limits of detection were 0.012–0.450 μg kg⁻¹ for milk and 0.023–0.690 μg kg⁻¹ for honey. Finally, the method was successfully applied to the quantification of QNs in milk and honey samples.

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金属有机骨架UiO-66-NH2功能化聚多巴胺修饰磁性多壁碳纳米管用于十六种喹诺酮类药物的磁固相萃取

在本研究中，基于金属-有机骨架UiO-66-NH2功能化聚多巴胺修饰磁性多壁碳纳米管（Fe3O4@MWCNTs@PDA@UiO-66-NH2）开发了一种新型磁性固相萃取吸附剂，用于选择性提取牛奶和蜂蜜中的微量喹诺酮（QNs）。在最佳条件下，与超高效液相色谱-串联质谱（UHPLC-MS/MS）联用，在0.1 ~ 100 μg kg−1 （R2 ≥ 0.9916）范围内具有良好的线性关系。16个qn的加样回收率为72.4 % ~ 108.9 %，相对标准偏差小于9.40 %。牛奶的检出限为0.012-0.450 μg kg−1，蜂蜜的检出限为0.023-0.690 μg kg−1。最后，该方法成功应用于牛奶和蜂蜜样品中qn的定量。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.