Design, Synthesis, and Antibacterial Activity of Stilbene Derivatives against Phytopathogenic Bacteria

IF 5.7 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-05-01 DOI:10.1021/acs.jafc.5c02030

Peng Deng, Jun-Xia An, Hong-Jie Liang, Guo-Liang Mou, Xiong-Fei Luo, Deng-Tuo Wang, Shao-Yong Zhang, Li Jing Zhang, Ya-Rui Jin, Zhi-Jun Zhang, Ying-Qian Liu

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Abstract

The increasing resistance of phytopathogenic bacteria to chemical pesticides has underscored the urgent need for novel bactericidal agents. In this study, we designed, synthesized, and evaluated a series of stilbene derivatives for their antibacterial activity against six strains of plant-pathogenic bacteria. Among them, compound ST-A-8 showed the optimal activity against Xanthomonas oryzae pv oryzae (Xoo) and Erwinia aroideae, with both MIC values of 1.56 μg/mL, which was more potent than the commercialized antibacterial agent thiodiazole copper. Furthermore, the mechanism of ST-A-8 on Xoo was preliminarily investigated, and the results showed that ST-A-8 inhibited the biofilm formation as well as the production of extracellular polysaccharides in Xoo. Additionally, it disrupted the integrity of the cell membrane and increased the production of ROS, leading to lipid peroxidation of the cell membrane. Therefore, compound ST-A-8 may serve as a potential novel bactericide for the control of plant bacterial diseases.

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二苯乙烯衍生物的设计、合成及对植物病原菌的抑菌活性研究

植物致病菌对化学农药的抗性日益增强，迫切需要新的杀菌剂。在本研究中，我们设计、合成并评价了一系列二苯乙烯衍生物对6株植物致病菌的抗菌活性。其中，化合物ST-A-8对米黄单胞菌pv oryzae （Xoo）和避免Erwinia roideae的抑菌活性最优，MIC值均为1.56 μg/mL，抑菌效果优于市售的硫代二唑铜。初步探讨了ST-A-8对Xoo的作用机制，结果表明ST-A-8对Xoo生物膜的形成和胞外多糖的产生具有抑制作用。此外，它破坏了细胞膜的完整性，增加了ROS的产生，导致细胞膜脂质过氧化。因此，化合物ST-A-8可能作为一种潜在的新型杀菌剂用于植物细菌性病害的防治。

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.