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IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-01

Yuwei Zhong, Claude Desplan

引用次数: 0

Abstract

During human brain development, billions of neurons need to recognize their partners to form neuronal circuits. To explain this striking specificity, the chemoaffinity hypothesis proposes that neurons bear molecular identification tags (e.g., cell surface proteins) that distinguish them from one another and establish specific connections (1). Although this idea has been validated in some cases, given the limited number of cell surface proteins encoded by the genome, it is unlikely that such large numbers of neurons could rely solely on strict chemoaffinity to establish complicated neuronal networks (2). This problem might become insurmountable when the neurons have to find their targets in a three-dimensional (3D) environment. On page 538 of this issue, Lyu et al. (3) report that olfactory neurons in the fruit fly (Drosophila) solve this problem by reducing the dimensionality of the search path. These findings could help understand the wiring of the more complex mammalian brain.

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在人类大脑发育过程中，数十亿的神经元需要识别它们的伙伴来形成神经元回路。为了解释这种惊人的特异性，化学亲和假说提出神经元具有分子识别标签（例如，细胞表面蛋白），使它们彼此区分并建立特定的联系(1)。尽管这一观点在某些情况下得到了验证，但考虑到基因组编码的细胞表面蛋白数量有限，如此大量的神经元不太可能仅仅依靠严格的化学亲和性来建立复杂的神经元网络(2)。当神经元必须在三维（3D）环境中找到它们的目标时，这个问题可能变得难以克服。在本期的第538页，Lyu等人(3)报道了果蝇（Drosophila）的嗅觉神经元通过降低搜索路径的维数来解决这个问题。这些发现可以帮助理解更复杂的哺乳动物大脑的线路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

期刊介绍： Science is a leading outlet for scientific news, commentary, and cutting-edge research. Through its print and online incarnations, Science reaches an estimated worldwide readership of more than one million. Science’s authorship is global too, and its articles consistently rank among the world's most cited research. Science serves as a forum for discussion of important issues related to the advancement of science by publishing material on which a consensus has been reached as well as including the presentation of minority or conflicting points of view. Accordingly, all articles published in Science—including editorials, news and comment, and book reviews—are signed and reflect the individual views of the authors and not official points of view adopted by AAAS or the institutions with which the authors are affiliated. Science seeks to publish those papers that are most influential in their fields or across fields and that will significantly advance scientific understanding. Selected papers should present novel and broadly important data, syntheses, or concepts. They should merit recognition by the wider scientific community and general public provided by publication in Science, beyond that provided by specialty journals. Science welcomes submissions from all fields of science and from any source. The editors are committed to the prompt evaluation and publication of submitted papers while upholding high standards that support reproducibility of published research. Science is published weekly; selected papers are published online ahead of print.