Stem cells as role models for reprogramming and repair

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-01

Magdalena Götz, Maria-Elena Torres-Padilla

引用次数: 0

Abstract

Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decades. This ability is currently being exploited for therapies using strategies to repair or replace damaged tissues and cells or to alleviate immune rejection. Exploring stem cell function has enabled direct reprogramming approaches, for example, through the production of induced pluripotent stem cells and the generation of tissue-specific stem cells. Understanding stem cell function has emerged as an important strategy for repopulating stem cell pools or generating differentiated cells for therapy. Here, we review general principles of mammalian stem cell biology and cellular reprogramming approaches and their use for current and future therapeutic purposes.

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干细胞作为重编程和修复的榜样

干细胞在许多疾病和组织的细胞治疗中是一个很有前途的来源。它们分化为其他细胞类型的内在能力是几十年来研究的焦点。这种能力目前正被用于修复或替换受损组织和细胞或减轻免疫排斥的治疗策略。探索干细胞功能使直接重编程方法成为可能，例如，通过诱导多能干细胞的产生和组织特异性干细胞的产生。了解干细胞的功能已成为重新填充干细胞库或产生用于治疗的分化细胞的重要策略。在这里，我们回顾了哺乳动物干细胞生物学和细胞重编程方法的一般原理及其在当前和未来治疗目的中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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