Discovery research in physiologically maintained deceased

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-01

Douglas B. Pet, Brendan Parent, Neel S. Singhal, Claire D. Clelland

引用次数: 0

Abstract

Deceased humans in whom ventilation and circulation are maintained for a defined period after the declaration of death by neurologic criteria (brain death), referred to here as physiologically maintained deceased (PMD), mimic live human physiology, providing highly valuable research opportunities. Medical research involving PMDs has narrowed translational gaps and ushered in groundbreaking treatments, including the transplantation of gene-edited organs into living human patients (1). However, the potential of PMDs remains largely untapped for human therapeutic discovery research. PMDs may be particularly advantageous in discovering and advancing new therapies, such as gene therapies, that are human specific and therefore are limited by nonhuman research models. We envision PMD research as a transformative force for human therapeutic discovery and emphasize the importance of upholding established bioethical standards and pursuing ongoing ethical inquiry to ensure the protection of all stakeholders.

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研究发现死者的生理维持

根据神经学标准（脑死亡）宣布死亡后，在规定的时间内保持通气和血液循环的死者，在这里称为生理维持死者（PMD），模仿活人的生理，提供了极有价值的研究机会。涉及pmd的医学研究已经缩小了翻译差距，并带来了突破性的治疗方法，包括将基因编辑的器官移植到活体人类患者身上(1)。然而，经PMDs的潜力在很大程度上仍未被用于人类治疗发现研究。pmd在发现和推进新疗法方面可能特别有利，例如基因疗法，这是人类特有的，因此受到非人类研究模型的限制。我们将PMD研究设想为人类治疗发现的变革性力量，并强调维护已建立的生物伦理标准和追求持续的伦理调查的重要性，以确保保护所有利益相关者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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