Elevated Serum Histamine N-Methyltransferase Levels Are Associated With the Pathophysiology of Major Depressive Disorder: A Case–Control Study

IF 2.7 4区 医学 Q2 DEVELOPMENTAL BIOLOGY
Mariya Akter, Dibbo Protim Ghosh, Toha Tasnem, Tanvir Ahmed, Md. Aminul Haque, Md. Siddiqul Islam, Md. Rabiul Islam
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Abstract

Major depressive disorder (MDD) is a common neuropsychiatric disorder with persistent low mood, feelings of weakness, and a lack of interestin daily tasks. Histamine N-methyltransferase (HNMT) protein is involved in the inactivation process of histamine in human physiology. Here, we aimed to assess the role of HNMT in the pathophysiology and development of MDD. This case–control study included 56 MDD patients and 32 healthy controls (HCs) by matching age, sex, body mass index (BMI), and other sociodemographic characteristics. A clinical psychiatrist assessed the MDD patients and HCs according to the DSM-5 criteria. We used the Ham-D scale in evaluating the severity of depressive symptoms. We used ELISA kits to estimate serum HNMT levels. We observed elevated serum HNMT concentration in MDD patients (29.25 ± 5.34 pg/ml) compared with HCs (23.13 ± 2.10 pg/ml). Serum HNMT levels and Ham-D scores are positively correlated with each other in MDD patients (r = 0.632, p < 0.001). Also, the receiver operating characteristic curve analysis illustrated a significant diagnostic value for HNMT with the area under the curve (AUC = 0.916) at p < 0.001. The promising findings from this study anticipate that the elevated serum levels of HNMT may be associated with the pathophysiology and mechanism of MDD. We recommend further interventional studies to produce more precise and accurate results on this biomarker in depression.

血清组胺n -甲基转移酶水平升高与重度抑郁症的病理生理相关:一项病例对照研究
重度抑郁症(MDD)是一种常见的神经精神障碍,表现为持续的情绪低落、虚弱感和对日常工作缺乏兴趣。组胺n -甲基转移酶(HNMT)蛋白参与人体生理中组胺的失活过程。在这里,我们的目的是评估HNMT在重度抑郁症的病理生理和发展中的作用。本病例对照研究通过匹配年龄、性别、体重指数(BMI)和其他社会人口学特征,纳入56例重度抑郁症患者和32例健康对照(hc)。临床精神科医生根据DSM-5标准对重度抑郁症患者和丙型肝炎患者进行评估。我们使用Ham-D量表来评估抑郁症状的严重程度。我们使用ELISA试剂盒估计血清HNMT水平。我们观察到MDD患者血清HNMT浓度(29.25±5.34 pg/ml)高于hc患者(23.13±2.10 pg/ml)。MDD患者血清HNMT水平与Ham-D评分呈正相关(r = 0.632, p <;0.001)。此外,受试者工作特征曲线分析显示,曲线下面积(AUC = 0.916)在p <时对HNMT具有显著的诊断价值;0.001. 本研究的结果表明,血清HNMT水平升高可能与重度抑郁症的病理生理和发病机制有关。我们建议进一步的介入研究,以获得更精确和准确的抑郁症生物标志物的结果。
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来源期刊
Developmental Neurobiology
Developmental Neurobiology 生物-发育生物学
CiteScore
6.50
自引率
0.00%
发文量
45
审稿时长
4-8 weeks
期刊介绍: Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.
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