Anti-inflammatory effect of food bioactives in inflammatory bowel disease: Role of the gut microbiome

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-04-27 DOI:10.1016/j.fbio.2025.106710

Yawei Zhang , Lufan Zhang , Yang Dong , Yunwei Yang , Mengxing Li , Qian Chen , Dan Wang , Yuzheng Wu , Tao Wang

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引用次数: 0

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory condition characterized by recurrent inflammation of the gastrointestinal tract. Its pathogenesis is multifactorial, but accumulating evidence has highlighted that the homeostasis of the microbiome plays a remarkable role in the development and treatment of IBD. The commensal microbiome supports the development of the mucosal immune system as well as the proper function of the intestinal epithelial barrier. However, the pathogenic microbiome leads to inflammation and intestinal epithelial barrier dysfunction, resulting in disease development. Natural food bioactives, including polyphenols, polysaccharides, terpenoids, glycosides, etc., provide a protective benefit for IBD by exerting immunomodulatory effects and barrier repair function by altering gut microbiota. Therefore, in this review, we focused on the anti-inflammatory mechanisms and intestinal barrier repair mechanisms of natural food bioactives behind the action of the gut microbiota. The improved understanding of the properties of food bioactives in regulating gut microbiota will facilitate their application in improving nutritional strategies and management of IBD.

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食物生物活性物在炎症性肠病中的抗炎作用：肠道微生物组的作用

炎症性肠病（IBD）是一种以胃肠道复发性炎症为特征的慢性炎症。其发病机制是多因素的，但越来越多的证据表明，微生物组的稳态在IBD的发展和治疗中起着显著的作用。共生菌群支持粘膜免疫系统的发育以及肠上皮屏障的正常功能。然而，致病微生物组导致炎症和肠上皮屏障功能障碍，导致疾病发展。天然食品生物活性物质，包括多酚类、多糖类、萜类、苷类等，通过改变肠道菌群，发挥免疫调节作用和屏障修复功能，对IBD具有保护作用。因此，本文就天然食品生物活性物质在肠道菌群作用背后的抗炎机制和肠道屏障修复机制进行综述。提高对食品生物活性物质调节肠道菌群特性的认识将有助于其在改善营养策略和IBD管理方面的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.