Development and validation of a highly sensitive method for the analysis of succinate dehydrogenase inhibitors (SDHIs) in plant-based food and beverages

IF 9.8 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-04-26 DOI:10.1016/j.foodchem.2025.144532

Camille Pasquet , Sylvie Guinchard , Marie Villier , Eléa Guyaz , Jean-Marc Bonmatin , Gaetan Glauser

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引用次数: 0

Abstract

Recently, concerns have been raised over succinate dehydrogenase inhibitor (SDHI) fungicides and their potential adverse effects on the environment and nontarget organisms including humans. Appropriate analysis methods are thus necessary for their proper risk assessment. Here, a highly sensitive method based on QuEChERS and UHPLC-MS/MS was developed and validated for the simultaneous quantification of 12 SDHIs and seven of their metabolites in beverages, fruits and vegetables. The method displayed linearity over more than three orders of magnitude, precision with RSD <20 % and recoveries between 70 and 120 % for all compounds, ensuring robustness across a wide concentration range. Limits of quantification as low as 0.003–0.3 ng/g depending on the matrix and analytes were reached. The method was applied to 28 representative samples of fruits, vegetable, fruit juices, wine and water samples. The results illustrate the reliability of this method for the quantification of SDHI fungicides in a variety of foodstuff matrices.

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植物性食品和饮料中琥珀酸脱氢酶抑制剂（SDHIs）高灵敏度分析方法的建立和验证

最近，琥珀酸脱氢酶抑制剂（SDHI）杀菌剂及其对环境和包括人类在内的非目标生物的潜在不利影响引起了人们的关注。因此，需要适当的分析方法来进行适当的风险评估。本文建立了一种基于QuEChERS和UHPLC-MS/MS的高灵敏度方法，用于同时定量饮料、水果和蔬菜中12种SDHIs及其7种代谢物。该方法具有3个数量级以上的线性关系，精密度的RSD为20 %，加样回收率在70 ~ 120 %之间，确保了在较宽的浓度范围内的稳健性。根据基质和分析物的不同，定量限低至0.003-0.3 ng/g。将该方法应用于28种具有代表性的水果、蔬菜、果汁、葡萄酒和水样。结果表明，该方法可用于多种食品基质中SDHI杀菌剂的定量分析。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.