Effect of the Chilean Bean Landrace Peumo on Metabolic Syndrome‐Related Parameters in C57BL/6 Mice Fed With a High‐Fat Diet

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-04-26 DOI:10.1002/mnfr.70089

Felipe Avila, Daniel Droguett, Cristina Theoduloz, Guillermo Schmeda‐Hirschmann

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Abstract

Scope: We report a nutritional intervention involving supplementation with boiled beans and secondary metabolites‐enriched extracts (SMEEs) from a Chilean Phaseolus vulgaris landrace in mice with induced metabolic syndrome (MS).Methods and results: The effects of supplementation were assessed in C57BL6 mice with MS induced by a high‐fat diet. Boiled beans (75 and 150 mg animal day−1) and the SMEE (0.8 and 8 mg animal day−1) were administered daily for 4 months. Weight and glycemia were measured weekly. At the end of the experiment, glycemia, total, high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) cholesterol, triglycerides, protein carbonyls, and carboxymethyl lysine (CML) levels were determined in plasma. Oral intake of the SMEE decreased glycemia at the end of the intervention. No statistically significant difference in glycemia was found for the boiled beans compared with controls. The SMEE at 0.8 mg animal day−1 decreased the total amount of CML, mainly in proteins with molecular masses >75 kDa, in agreement with the results for carbonylated proteins.Conclusion: The SMEE of Peumo beans reduces glycemia at the end of the intervention and decreases total CML in plasma, suggesting a potential beneficial effect of bean intake. The results obtained in the intervention encourage further studies in Chilean bean landraces.

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智利土豆豆Peumo对饲喂高脂饮食的C57BL/6小鼠代谢综合征相关参数的影响

范围：我们报道了一项营养干预，包括补充煮熟的豆类和智利菜豆次生代谢物富集提取物（SMEEs），用于诱导代谢综合征（MS）小鼠。方法和结果：在高脂饮食诱导的多发性硬化症C57BL6小鼠中评估了补充剂的效果。每天给煮豆（动物日- 1 75和150 mg）和SMEE（动物日- 1 0.8和8 mg），持续4个月。每周测量体重和血糖。实验结束时，测定血浆中血糖、总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）、甘油三酯、蛋白羰基和羧甲基赖氨酸（CML）水平。干预结束时口服SMEE可降低血糖。与对照组相比，煮熟的豆子在血糖水平上没有统计学上的显著差异。0.8 mg动物d - 1的SMEE降低了CML的总量，主要是分子质量为75 kDa的蛋白质，这与羰基化蛋白质的结果一致。结论：Peumo豆的SMEE在干预结束时降低血糖，降低血浆中总CML，提示豆类摄入可能具有有益作用。在干预中获得的结果鼓励了对智利地方豆品种的进一步研究。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.