Polymer Scaffolds for peripheral nerve injury repair

IF 33.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Progress in Materials Science Pub Date : 2025-04-24 DOI:10.1016/j.pmatsci.2025.101497

Shuhang Yang , Li Chen , Chuhang Bai , Shiguang Zhao , Haining Wu , Xingli Dong , Yuanfeng Wang , Yun Qian , Bing Du , Shiguo Chen

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引用次数: 0

Abstract

The peripheral nervous system (PNS) plays a vital role in regulating physiological functions, and it is closely related to one’s quality of life. Unfortunately, various factors such as natural disasters, congenital diseases, accidents, degenerative diseases, and surgical injuries can cause serious damage to the nervous system, so peripheral nerve injury (PNI) repair has emerged as a highly researched and important research field. Autologous nerve transplantation has been regarded as the “gold standard” for PNI repair, while it is far from optimal owing to the limited availability and length of donor nerves, morbidity at the donor site, and the request for secondary surgery. Therefore, it is very urgent to find an alternative solution to repair damaged nervous system. Employing polymer scaffold is one promising strategy in PNI repair due to their regulated microstructures with specific length and size, superior comprehensive mechanical properties, large-scale preparation with unlimited source, unrequired secondary surgery, and tailored degradation rate. Herein, to assist readers in comprehensively understanding polymer scaffolds for PNI repair, we summarized the polymer scaffolds based on scaffold microenvironment, materials, molding methods, and main challenges in PNI repair. Finally, we put forward their future development trends and some key issues be addressed urgently.

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聚合物支架用于周围神经损伤修复

外周神经系统（PNS）在调节人体生理功能中起着至关重要的作用，它与人的生活质量密切相关。不幸的是，自然灾害、先天性疾病、意外事故、退行性疾病、手术损伤等各种因素都会对神经系统造成严重的损伤，因此周围神经损伤（PNI）修复已成为一个被高度研究和重要的研究领域。自体神经移植被认为是修复PNI的“金标准”，但由于供体神经的可用性和长度有限、供体部位的发病率以及需要二次手术等原因，它远非最佳选择。因此，寻找一种修复受损神经系统的替代方案是非常迫切的。聚合物支架具有特定长度和尺寸的可调节的微观结构，优越的综合力学性能，无限量的大规模制备，无需二次手术，可定制的降解率，是修复PNI的一种很有前途的策略。为了帮助读者全面了解用于PNI修复的聚合物支架，我们从支架微环境、材料、成型方法以及PNI修复面临的主要挑战等方面对聚合物支架进行了综述。最后，提出了其未来发展趋势和亟待解决的关键问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in Materials Science 工程技术-材料科学：综合

CiteScore

59.60

自引率

0.80%

发文量

101

审稿时长

11.4 months

期刊介绍： Progress in Materials Science is a journal that publishes authoritative and critical reviews of recent advances in the science of materials. The focus of the journal is on the fundamental aspects of materials science, particularly those concerning microstructure and nanostructure and their relationship to properties. Emphasis is also placed on the thermodynamics, kinetics, mechanisms, and modeling of processes within materials, as well as the understanding of material properties in engineering and other applications. The journal welcomes reviews from authors who are active leaders in the field of materials science and have a strong scientific track record. Materials of interest include metallic, ceramic, polymeric, biological, medical, and composite materials in all forms. Manuscripts submitted to Progress in Materials Science are generally longer than those found in other research journals. While the focus is on invited reviews, interested authors may submit a proposal for consideration. Non-invited manuscripts are required to be preceded by the submission of a proposal. Authors publishing in Progress in Materials Science have the option to publish their research via subscription or open access. Open access publication requires the author or research funder to meet a publication fee (APC). Abstracting and indexing services for Progress in Materials Science include Current Contents, Science Citation Index Expanded, Materials Science Citation Index, Chemical Abstracts, Engineering Index, INSPEC, and Scopus.