Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle in the United States

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-04-25 DOI:10.1126/science.adq0900

Thao-Quyen Nguyen, Carl R. Hutter, Alexey Markin, Megan Thomas, Kristina Lantz, Mary Lea Killian, Garrett M. Janzen, Sriram Vijendran, Sanket Wagle, Blake Inderski, Drew R. Magstadt, Ganwu Li, Diego G. Diel, Elisha Anna Frye, Kiril M. Dimitrov, Amy K. Swinford, Alexis C. Thompson, Kevin R. Snekvik, David L. Suarez, Steven M. Lakin, Stacey Schwabenlander, Sara C. Ahola, Kammy R. Johnson, Amy L. Baker, Suelee Robbe-Austerman, Mia Kim Torchetti, Tavis K. Anderson

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引用次数: 0

Abstract

Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, poultry, and mammals. Our genomic analysis and epidemiological investigation showed that a reassortment event in wild bird populations preceded a single wild bird–to-cattle transmission episode. The movement of asymptomatic or presymptomatic cattle has likely played a role in the spread of HPAI within the United States dairy herd. Some molecular markers that may lead to changes in transmission efficiency and phenotype were detected at low frequencies. Continued transmission of H5N1 HPAI within dairy cattle increases the risk for infection and subsequent spread of the virus to human populations.

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高致病性甲型H5N1禽流感在美国奶牛中的出现和州际传播

高致病性禽流感（HPAI）病毒跨越物种障碍，有可能造成大流行。在北美，与鹅/广东 2.3.4.4b 血凝素系统发育支系相关的甲型 H5N1 高致病性禽流感病毒感染了野鸟、家禽和哺乳动物。我们的基因组分析和流行病学调查显示，在一次野鸟对牛的传播事件之前，野鸟种群中发生了一次重配事件。无症状或症状不明显的牛的移动很可能是高致病性禽流感在美国奶牛群中传播的原因之一。一些可能导致传播效率和表型变化的分子标记被低频检测到。H5N1 高致病性禽流感在奶牛中的持续传播增加了病毒感染和随后向人类传播的风险。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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