Development of brain metastable dynamics during the equivalent of the third gestational trimester

Abstract

Metastability, a concept from dynamical systems theory, provides a framework for understanding how the brain shifts between various functional states and underpins essential cognitive, behavioural, and social function. While studied in adults, metastability in early brain development has only received recent attention. As the brain undergoes dramatic functional and structural changes over the third gestational trimester, here we review how these are reflected in changes in brain metastable dynamics in preterm, preterm at term-equivalent and full-term neonates.

We synthesize findings from EEG, fMRI, fUS, and computational models, focusing on the spatial distribution and temporal dynamics of metastable states, which include functional integration and segregation, signal predictability and complexity. Despite fragmented evidence, studies suggest that neonatal metastability develops over the equivalent of the third gestational trimester, with increasing ability for integration-segregation, broader range of metastable states, faster metastable state transitions and greater signal complexity. Preterms at term-equivalent age exhibit immature metastability features compared to full-terms. We explain and interpret these changes in terms of maturation of the brain in a free energy landscape and establishment of cognitive functions.