Bo-ming Liang, Mu-yao Wang, Chang-cheng Ji, Xin Qi, Cheng-bi Cui
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引用次数: 0
Abstract
This study aims to investigate the role of hazelnut leaf polyphenols (HLP) in regulating chronic alcoholic liver damage (CALD) and explore its possible molecular mechanisms. By measuring the scavenging rates of DPPH·, ABTS+, and ·OH, as well as the reducing power and total antioxidant capacity, the antioxidant activity of HLP was evaluated. Both in vivo and in vitro experiments were conducted to examine the effects of HLP on CALD. The results showed that HLP exhibits strong antioxidant activity and within a certain concentration range, can regulate ethanol-induced oxidative stress levels in LO2 cells. Additionally, HLP improves liver function by modulating the Nrf2/Keap1 pathway, reducing ALT and AST levels in mice, and correcting the body's redox imbalance. This protective effect helps shield the liver from ethanol-induced damage, revealing that hazelnut leaf polyphenols possess potent antioxidant properties and significantly improve CALD.
期刊介绍：
eFood is the official journal of the International Association of Dietetic Nutrition and Safety (IADNS) which eFood aims to cover all aspects of food science and technology. The journal’s mission is to advance and disseminate knowledge of food science, and to promote and foster research into the chemistry, nutrition and safety of food worldwide, by supporting open dissemination and lively discourse about a wide range of the most important topics in global food and health.
The Editors welcome original research articles, comprehensive reviews, mini review, highlights, news, short reports, perspectives and correspondences on both experimental work and policy management in relation to food chemistry, nutrition, food health and safety, etc. Research areas covered in the journal include, but are not limited to, the following:
● Food chemistry
● Nutrition
● Food safety
● Food and health
● Food technology and sustainability
● Food processing
● Sensory and consumer science
● Food microbiology
● Food toxicology
● Food packaging
● Food security
● Healthy foods
● Super foods
● Food science (general)
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