Determination of the migration of six bisphenols from cans and sport bottles using rapid synergistic cloud point extraction and high-performance liquid chromatography

Abstract

Bisphenols migration from food packaging poses contamination risks, necessitating sensitive detection methods for trace-level quantification. A novel method was established for preconcentration and determination of six bisphenols (bisphenol E, bisphenol A, bisphenol B, bisphenol AF, bisphenol C, and bisphenol PH). After rapid synergistic cloud point extraction as the pretreatment technology, and high-performance liquid chromatography was carried out, and the analytes in surfactant-rich phase supernatant were detected fluorometrically. Genapol X-080 was specially selected as the extractant, while acetonitrile was the cloud revulsant and synergistic reagent. Under the optimum conditions, the correlation coefficients among target substances were all higher than 0.998 in the range of 0.125 −35.0 μg/kg. The relative standard deviations were lower than 5.3 %, and the detection limit range was 0.024 −0.032 μg/kg. High extraction efficiencies (89.2 %−99.3 %) and enhancement factors (16.2 −18.1) of the six bisphenols were achieved. The suitability of this method for the analysis of food simulants from two types of food contact materials was demonstrated and the recoveries ranged from 84.4 % to 108 %. The proposed method was simple, economical, highly efficient, and sensitive, also could separate and preconcentrate of trace or ultra-trace bisphenols in foodstuffs.