Evaluating palm olein and palm stearin on hepatic lipids in C57BL/6 J mice under low and high fat intakes: A quantitative lipidomic approach

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-04-12 DOI:10.1016/j.foodchem.2025.144326

Liting Wan , Lin Li , Xia Zhang , Bing Li , Kristen J. Brao , Janette M. Harro , Mark E. Shirtliff

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Abstract

This work aims to study the effects of dietary lipid content and composition on hepatic lipids of mice fed palm olein (PO)-based low-fat diet, PO-based high-fat diet, palm stearin (PS)-based low-fat diet, or PS-based high-fat diet for 8 weeks. Results showed that high PO and PS intake significantly elevated serum LDL-c and TCHO levels and hepatic TG content without altering the expression levels of genes involved in DNL. Overall, quantitative lipidomics revealed that accumulated lipids were polyunsaturated PE and saturated & monounsaturated SM/Cer_NS in response to high PO intake. While high PS intake led to increased levels of polyunsaturated PC and mono- & polyunsaturated TG. These enriched lipids may lead to disturbed hepatic PUFA metabolism. When lipid intake was constant, only under high fat intake did PS show minor effects on hepatic lipids. These results highlighted the role of lipid quantity instead of lipid quality on hepatic lipid profiles.

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评估棕榈油素和棕榈硬脂对低脂和高脂摄入的 C57BL/6 J 小鼠肝脏脂质的影响：定量脂肪组学方法

本研究旨在研究膳食脂质含量和组成对小鼠肝脏脂质的影响，小鼠分别以棕榈油油脂（PO）为基础的低脂膳食、以PO为基础的高脂膳食、以棕榈硬脂（PS）为基础的低脂膳食或以PS为基础的高脂膳食喂养8周。结果表明，PO 和 PS 的高摄入量会显著提高血清 LDL-c 和 TCHO 水平以及肝脏 TG 含量，但不会改变参与 DNL 的基因的表达水平。总体而言，定量脂质组学显示，在摄入大量 PO 的情况下，累积的脂质为多不饱和 PE 和饱和&；单不饱和 SM/Cer_NS。而摄入大量 PS 会导致多不饱和 PC 和单不饱和 TG 水平升高。这些富集的脂类可能会导致肝脏多不饱和脂肪酸代谢紊乱。当脂质摄入量不变时，只有在高脂肪摄入的情况下，PS 才会对肝脏脂质产生轻微影响。这些结果凸显了脂质数量而非脂质质量对肝脏脂质状况的影响。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.