Interaction between dietary selenium intake and age on severe headache or migraine in the United States: a population-based study.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1537151

Xinping Yu, Lanxiang Wu, Heqing Zheng, Wei Wu, Sheng Tian

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Abstract

Background: Studies have shown that an antioxidant diet is a protective factor against migraine. However, the association between selenium, an important antioxidant consumed from the diet, and migraine has received little attention. The aim of this study was to explore the relationship between dietary selenium intake with migraine, with particular interest in age differences.

Methods: This study based on cross-sectional data from people who took part in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. The multiple logistic regression model was applied to examine the association between selenium intake and migraine, and subgroup analyses were performed. Non-linear associations were explored with restricted cubic spline (RCS) models.

Results: The study included a total of 9,849 adults aged 20 years and older. Compared with individuals with lowest selenium intake Q1 (≤59.4 ug/day), the adjusted OR values for selenium intake and migraine in Q2 (59.41-82.70 ug/day), Q3 (82.71-106 ug/day), Q4 (106.01-143.16 ug/day), and Q5 (≥143.17 ug/day) were 0.82 (95% CI: 0.64-1.05), 0.99 (95% CI: 0.77-1.26), 0.74 (95% CI: 0.54-0.99), and 0.68 (95% CI: 0.48-0.97), respectively. Sensitivity analyses showed a robust association between them. Our findings also suggested an interaction between age and selenium intake (p for interaction = 0.04). Additionally, the relationship between selenium intake and migraine in adults with 20-50 years was L-shaped. The OR of developing migraine was 0.97 (95% CI: 0.94-0.98) in individuals with selenium intake ≥101.9 ug/day in adults with 20-50 years.

Conclusion: A higher dietary selenium intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them. Therefore, the present study indicate that an appropriate intake of selenium-rich foods in adults aged 20-50 years may prevent migraines.

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膳食硒摄入量与年龄对美国严重头痛或偏头痛的影响：一项基于人群的研究

背景：研究表明，抗氧化饮食是偏头痛的保护因素。然而，从饮食中摄入的重要抗氧化剂硒与偏头痛之间的关系却很少受到关注。本研究旨在探讨膳食硒摄入量与偏头痛之间的关系，尤其关注年龄差异：本研究基于 1999 年至 2004 年间参加美国国家健康与营养调查（NHANES）的横断面数据。采用多元逻辑回归模型研究硒摄入量与偏头痛之间的关系，并进行了亚组分析。利用限制性立方样条（RCS）模型探讨了非线性关联：研究共纳入了 9849 名 20 岁及以上的成年人。与硒摄入量最低的 Q1（≤59.4 微克/天）相比，硒摄入量与偏头痛的调整 OR 值在 Q2（59.41-82.70 微克/天）、Q3（82.71-106 微克/天）、Q4（106.01-143.16微克/天）和Q5（≥143.17微克/天）分别为0.82（95% CI：0.64-1.05）、0.99（95% CI：0.77-1.26）、0.74（95% CI：0.54-0.99）和0.68（95% CI：0.48-0.97）。敏感性分析表明，两者之间存在密切联系。我们的研究结果还表明，年龄与硒摄入量之间存在交互作用（交互作用的 p = 0.04）。此外，在 20-50 岁的成年人中，硒摄入量与偏头痛之间的关系呈 "L "形。在 20-50 岁的成年人中，硒摄入量≥101.9 微克/天的人患偏头痛的 OR 值为 0.97（95% CI：0.94-0.98）：结论：膳食中硒的摄入量越高，偏头痛的发病率就越低，而年龄会改变两者之间的关系。因此，本研究表明，20-50 岁的成年人适当摄入富硒食物可预防偏头痛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.