Sohrab Rahmani, Ali Roohbakhsh, Yazdan Hasani Nourian, Gholamreza Karimi
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引用次数: 0
Abstract
Mitochondria are essential for maintaining health, and dysfunction of them leads to various diseases. Their role is not limited to energy production but serves multiple mechanisms varying from calcium hemostasis, reactive oxygen species production, and regulation of apoptotic cell death. In recent years, several strategies have been developed to preserve mitochondria. Ellagic acid (EA) is a polyphenol extracted from many plants. The intestinal microflora converts EA to urolithins with high bioavailability. EA and urolithins exhibit mitochondrial-protective effects by regulating mitochondrial complexes, sirtuins, mitophagy, and mitochondrial antioxidant enzymes. This review highlights the mito-protective effects of EA and urolithins on mitochondrial injuries induced by various drugs and toxic compounds.
线粒体对维持健康至关重要，其功能障碍会导致各种疾病。线粒体的作用不仅限于产生能量，它还服务于多种机制，包括钙离子止血、活性氧生成和细胞凋亡调节。近年来，人们开发了多种策略来保护线粒体。鞣花酸（EA）是从许多植物中提取的一种多酚。肠道微生物菌群可将鞣花酸转化为具有高生物利用率的尿石素。EA 和尿磷脂通过调节线粒体复合物、sirtuins、丝裂噬和线粒体抗氧化酶，显示出保护线粒体的作用。本综述重点介绍了 EA 和尿石素对各种药物和有毒化合物引起的线粒体损伤的线粒体保护作用。
期刊介绍：
Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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