Sodium alginate hydrogel beads loaded with clove essential oil liposomes: Preparation, characterization and fumigant activity

IF 8.5 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Chemistry Pub Date : 2025-04-08 DOI:10.1016/j.foodchem.2025.144240

Fei Hu , Zhong-Liang Ji , Ai Zhang , Kiran Thakur , Jian-Guo Zhang , Zhao-Jun Wei

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Abstract

This study successfully developed a stable and effective delivery system for clove essential oil (CEO) using combination of liposomes and hydrogel beads via thin-film hydration method. Chitosan (CH) was incorporated for protection, and β-cyclodextrin (β-CD) was used in combination with sodium alginate and calcium ions to form the hydrogel beads. The liposome encapsulation efficiency of CEO was 87.26 % and loading efficiency was 27.08 %, while the hydrogel beads (HB) were 71.78 % and 14.35 %, respectively. The incorporation of CH and β-CD into sodium alginate hydrogel beads improved the thermal stability of CEO. The HB displayed excellent slow-release properties, retaining 22.47 % of the essential oil after 30 days of storage. The hydrogel beads facilitated a gradual release of CEO over 24 h, minimizing direct cellular exposure and mitigating toxicity. CEO exhibited fumigant toxicity towards Sitophilus oryzae adults, and the slow-release HB maintained a lethality rate of 11.11 % to S. oryzae adults after 30 days, which inhibited the activities of detoxification enzymes, acetylcholinesterase, and antioxidant enzymes. This delivery system provides a foundation for developing eco-friendly and effective pest control solutions using essential oils encapsulated in liposomal hydrogel beads.

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本研究采用薄膜水合法，将脂质体和水凝胶珠结合使用，成功开发了一种稳定有效的丁香精油（CEO）给药系统。脂质体中加入壳聚糖（CH）进行保护，β-环糊精（β-CD）与海藻酸钠和钙离子结合形成水凝胶珠。CEO 的脂质体包封效率为 87.26 %，负载效率为 27.08 %，而水凝胶珠（HB）的包封效率和负载效率分别为 71.78 % 和 14.35 %。在海藻酸钠水凝胶珠中加入 CH 和 β-CD 提高了 CEO 的热稳定性。HB 具有出色的缓释特性，储存 30 天后仍能保留 22.47% 的精油。水凝胶珠有助于 CEO 在 24 小时内逐渐释放，最大程度地减少了直接接触细胞的机会并减轻了毒性。CEO 对嗜线虫（Sitophilus oryzae）成虫具有熏蒸毒性，缓释 HB 在 30 天后对嗜线虫成虫的致死率保持在 11.11%，它抑制了解毒酶、乙酰胆碱酯酶和抗氧化酶的活性。这种递送系统为利用脂质体水凝胶珠包裹的精油开发环保、有效的害虫控制解决方案奠定了基础。

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来源期刊

Food Chemistry 工程技术-食品科技

CiteScore

16.30

自引率

10.20%

发文量

3130

审稿时长

122 days

期刊介绍： Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.