Multi-day recordings and adaptive stimulation protocols for in-home collection of deep brain stimulation intracranial recordings

IF 2.7 4区医学 Q2 BIOCHEMICAL RESEARCH METHODS

Journal of Neuroscience Methods Pub Date : 2025-04-04 DOI:10.1016/j.jneumeth.2025.110442

Jonathan P. Platt , Erin M. Radcliffe , Steven L. Klimczak , Stephen V. Gliske , Christopher K. Kovach , Dulce Maroni , Aviva Abosch , John A. Thompson

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引用次数: 0

Abstract

Background

While open-loop deep brain stimulation (DBS) is an effective therapy for the motor symptoms of Parkinson’s Disease (PD), recent work has explored whether closed-loop adaptive DBS (aDBS) may better address fluctuating symptoms through patient-specific and symptom-relevant neurophysiological biomarkers. To aid these investigations, we designed an interface for the research-enabled Summit Medtronic RC+S (RC+S) implanted neurostimulator (INS) to collect multi-day recordings along with the implementation of aDBS therapy.

New method

We developed applications in MATLAB for investigating optimal brain recording locations, setting thresholds for real-time analysis, determining the INS’s position along with in-home recordings of neural activity, and implementation of aDBS algorithms.

Results

In a pilot study conducted in PD subjects (n = 5), we successfully determined optimal DBS lead contacts for detecting maximal beta (13–30 Hz) activity for streaming in-home neural activity with closed-loop adjustments to stimulation amplitude (n = 24–27 days). Using a Bluetooth connection method we developed, 95.2 % in-home data was collected.

Comparison with existing methods

The software and hardware applications described in this report provide MATLAB based tools to enable a distributed strategy for interfacing with the RC+S deployed at in-home settings for multi-hour recordings.

Conclusions

Our interface provides investigators using the RC+S, in the context of aDBS, access to chronic recordings in real-time while providing adaptive stimulation based on continuous data analysis in MATLAB using a USB or Bluetooth connection. Advancing the efforts to characterize relevant biomarkers and develop therapeutic aDBS strategies for those treated with DBS, such as PD.

查看原文本刊更多论文

多天记录和自适应刺激方案在家庭收集深部脑刺激颅内记录。

背景：虽然开环脑深部刺激（DBS）是帕金森病（PD）运动症状的有效治疗方法，但最近的研究探索了闭环适应性脑深部刺激（aDBS）是否可以通过患者特异性和症状相关的神经生理生物标志物更好地解决波动症状。为了帮助这些研究，我们为研究启用的Summit Medtronic RC+S （RC+S）植入式神经刺激器（INS）设计了一个界面，用于收集aDBS治疗实施时的多天记录。新方法：我们在MATLAB中开发了应用程序，用于研究最佳的大脑记录位置，设置实时分析的阈值，确定INS的位置以及神经活动的家庭记录，以及自适应DBS算法的实现。结果：在PD受试者（n = 5）中进行的一项初步研究中，我们成功地确定了用于检测最大β (13-30Hz)活动的DBS导联触点，并对刺激幅度进行闭环调节（n = 24-27天）。使用我们开发的蓝牙连接方法，95.2%的家庭数据被收集。与现有方法的比较：本报告中描述的软件和硬件应用程序提供了基于MATLAB的工具，以实现与部署在家庭设置中的RC+S进行多小时记录的分布式策略。结论：我们的接口为研究人员提供了使用RC+S，在aDBS的背景下，实时访问长期记录，同时使用USB或蓝牙连接在MATLAB中提供基于连续数据分析的自适应刺激。推进相关生物标志物的鉴定工作，并为接受DBS治疗的患者（如PD）制定治疗aDBS的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroscience Methods 医学-神经科学

CiteScore

7.10

自引率

3.30%

发文量

226

审稿时长

52 days

期刊介绍： The Journal of Neuroscience Methods publishes papers that describe new methods that are specifically for neuroscience research conducted in invertebrates, vertebrates or in man. Major methodological improvements or important refinements of established neuroscience methods are also considered for publication. The Journal''s Scope includes all aspects of contemporary neuroscience research, including anatomical, behavioural, biochemical, cellular, computational, molecular, invasive and non-invasive imaging, optogenetic, and physiological research investigations.