[¹¹C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2025-04-04 DOI:10.1016/j.tins.2025.03.005

Aisling M Chaney, Brian A Gordon

引用次数: 0

Abstract

Accurately measuring brain inflammation in Alzheimer's disease (AD) is crucial due to the role of inflammatory processes in neurodegeneration. In a recent study, Appleton, Finn, et al. used [¹¹C]ER176, a novel translocator protein 18 kDa (TSPO)-positron emission tomography (PET) tracer overcoming genotype-related binding issues, to show increased inflammation in early-onset AD, with patterns aligning more closely with tau pathology than amyloid deposition or atrophy.

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[11]ER176在TSPO基因型中与tau共定位的脑炎症图像。

由于炎症过程在神经变性中的作用，准确测量阿尔茨海默病（AD）的脑部炎症至关重要。在最近的一项研究中，Appleton、Finn 等人利用新型转运蛋白 18 kDa（TSPO）--正电子发射断层扫描（PET）示踪剂 [11C]ER176 克服了基因型相关的结合问题，显示了早发性 AD 中炎症的增加，其模式与 tau 病理学的关系比淀粉样蛋白沉积或萎缩更为密切。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.

[11C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau.

Abstract

[¹¹C]ER176 images brain inflammation across TSPO genotypes and colocalizes with tau.