Determining the atlas correspondence of Desikan-Killiany-Tourville and Glasser MMP1 atlases across magnetic field strengths

Abstract

Background

Over sixty-six brain atlases exist to parcellate the brain based on cytoarchitecture, function, and connectivity. Because atlas choice depends on individual study goals and hypotheses, variability in findings contributes to challenges in replication, validation, and reconciling the results across studies. Our goal was to measure the intersection of three commonly used atlases and create a tool to find regional correspondence between the atlases.

New method

This study used three independent samples of anatomical MRI data acquired with different B0 magnetic field strengths: 1.5 Tesla (T), 3 T, and 7 T. The Desikan-Killiany- Tourville (DKT) and Glasser atlases were used to parcellate the brain. Coefficient-of- variation of regional volumes was measured to evaluate regional variability across subjects in each atlas. DKT and Glasser parcellation correspondence was calculated to answer the shared question of what Glasser regions intersect with a DKT region and vice versa and to investigate consistency of the parcellations in relation to each other across a variety of individuals and image resolutions.

Results

We found that regional correspondence was consistent across field strengths for the DKT and Glasser parcellations despite showing population variability in volume, age, and sex, and was validated in the Schaefer400 atlas. Parcellation intersection data along with sample code to calculate specific regional correspondence is available.

Comparison with existing methods

Prior studies have attempted to reconcile multiple atlases, but did not compare voxel- by-voxel on real data.

Conclusion

This analysis created a tool for researchers and can aid in comparisons with differing atlas choice and variable field strengths.