Relationship between composite dietary antioxidants index and growth indicators in children aged 3-12 years: results from two observational studies.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1551754

Rui Wen, Huanting Pei, Jingyi Ren, Siqi Zhu, Simeng Qiao, Pui Yee Tan, Yunyun Gong, Min Yang, Junsheng Huo, Gangqiang Ding, Yuxia Ma

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引用次数: 0

Abstract

Background: The intake of nutrients with antioxidant properties is closely related to numerous health outcomes. However, the evidence regarding the effects of antioxidant nutrient intake on children's growth indicators is still lacking. This study aimed to investigate the relationship between the Composite Dietary Antioxidant Index (CDAI) and child growth indicators in two cohorts.

Methods: This study utilized data from 1,064 participants in the Children's Cohort Study on Micronutrient Deficits and Malnutrition (CCSMDM) 2023 database and 2,404 participants from the National Health and Nutrition Examination Survey (NHANES) 2003-2020 database for cross-sectional analyses, with participants aged 3-12 years. The association between CDAI and growth indicators was analyzed using multinomial logistics regression. And we also performed subgroup analyses to determine whether there were differences in gender and explored the dose-response relationship by fitting a restricted cubic spline.

Results: After adjusting for potential confounders, CDAI was positively associated with children growth indicators (height: CCSMDM: OR =1.21, 1.04~1.43, p = 0.017; NHANES: OR = 1.11, 1.04~1.18, p = 0.001; weight: CCSMDM: OR =1.27, 1.09~1.52, p = 0.004; NHANES: OR = 1.12, 1.05~1.19, p < 0.001). Our study also found that there was a significant correlation between antioxidant nutrients (vitamin A, vitamin E, zinc, and magnesium) and height. And selenium, magnesium, and BMI were in close contact. Subgroup analysis found that CDAI had a higher positive association with height in male children.

Conclusions: Our study revealed the benefits of dietary antioxidant nutrients for children growth indicators. These results suggested that a higher level of dietary antioxidant nutrients may help to promote children growth indicators. It is recommended to consume a combination of multiple antioxidants, as their interactions may offer potential benefits. However, further research is needed to explore the underlying mechanisms of the synergistic effects of antioxidants on children's growth and development.

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3-12岁儿童复合膳食抗氧化剂指数与生长指标的关系：两项观察性研究的结果

背景：摄入具有抗氧化特性的营养素与许多健康结果密切相关。然而，关于抗氧化营养素摄入对儿童生长指标的影响的证据仍然缺乏。本研究旨在探讨复合膳食抗氧化指数（CDAI）与两组儿童生长指标的关系。方法：本研究利用来自微量营养素缺乏和营养不良儿童队列研究（CCSMDM） 2023数据库的1,064名参与者和来自国家健康与营养检查调查（NHANES） 2003-2020数据库的2,404名参与者的数据进行横断面分析，参与者年龄为3-12岁。采用多项logistic回归分析CDAI与增长指标之间的关系。我们还进行了亚组分析，以确定是否存在性别差异，并通过拟合限制三次样条来探索剂量-反应关系。结果：在调整潜在混杂因素后，CDAI与儿童生长指标呈正相关(身高：CCSMDM: OR =1.21, 1.04~1.43, p = 0.017；NHANES: OR = 1.11, 1.04~1.18, p = 0.001；CCSMDM: OR =1.27, 1.09~1.52, p = 0.004；NHANES: OR = 1.12, 1.05~1.19, p < 0.001)。我们的研究还发现，抗氧化营养素（维生素a、维生素E、锌和镁）与身高之间存在显著相关性。硒、镁和BMI密切相关。亚组分析发现，CDAI与男孩身高有较高的正相关。结论：我们的研究揭示了膳食抗氧化营养素对儿童生长指标的益处。这些结果提示，较高水平的膳食抗氧化营养素可能有助于促进儿童的生长指标。建议服用多种抗氧化剂的组合，因为它们的相互作用可能会带来潜在的好处。然而，抗氧化剂对儿童生长发育协同作用的潜在机制还有待进一步研究。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.