Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.

IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS
Frontiers in Nutrition Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1513088
Maha S Al-Odinan, Najlaa M Aljefree, Noha M Almoraie, Marwan A Bakarman, Hani A Alhadrami, Israa M Shatwan
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引用次数: 0

Abstract

Introduction: Transcription factor-7-like 2 (TCF7L2) is the most critical type 2 diabetes (T2D) gene identified to date. The single-nucleotide polymorphism (SNP) rs7903146 in TCF7L2 in T2D interacts with dietary factors; however, research on nutrigenetics among Saudi Arabians is limited. This study investigated the interaction between the SNP rs7903146 and dietary intake on factors that may contribute to MetS among Saudi Arabian adults.

Methods: This cross-sectional study included 271 adult participants (aged 20-55 years) of both genders with or without overweight or obesity (body mass index between 18-35 kg/m2). Anthropometric measurements and dietary assessments using a food frequency questionnaire were performed. Fasting blood samples were collected to analyze serum lipid, glucose, and insulin levels. Genetic analysis was performed using real-time polymerase chain reaction. Univariate regression was used to examine the association between the TCF7L2 SNP rs7903146 and laboratory parameters, and to test SNP-diet interactions. The additive model was used in the analysis and the T allele was the effect allele.

Results: A marginal significant association was observed between SNP rs7903146 and waist circumference (WC) (p = 0.05). Carriers of TT genotype had the highest WC (83.5 ± 20.1 cm), when compared with the CC genotype (80 ± 14.2 cm) and the TC genotype (77.9 ± 13.9 cm). The SNP rs7903146 was significantly associated with total energy intake (p = 0.04) and saturated fatty acids (SFA, p = 0.005), and TT carriers had the highest total energy and SFA consumption (3606.9 ± 1554.7 kcal, 66.8 ± 52.0 g, respectively). Only one near significant interaction was observed between SNP rs7903146 and total energy intake on insulin levels (p = 0.04), with carriers of the TT genotype showed a greater reduction in insulin values (-5.3 ± 3.5) at lower energy intake when compared with the CC (-2.4 ± 3.1), and TC (-4.7 ± 2.8). No significant interaction was found.

Conclusion: The present study observed significant associations between SNP rs7903146 and total energy and SFA consumptions. The TT carriers had increased consumption of total energy and SFA. Future studies using larger sample sizes are required to confirm significant interaction between SNP rs7903146 and diet on factors that may contribute to MetS in the Saudi population.

TCF7L2基因与饮食摄入对沙特阿拉伯成年人代谢综合征危险因素的相互作用
转录因子-7-样2 (TCF7L2)是迄今为止发现的最关键的2型糖尿病(T2D)基因。T2D患者TCF7L2单核苷酸多态性(SNP) rs7903146与饮食因素相互作用;然而,沙特阿拉伯人的营养遗传学研究是有限的。本研究调查了SNP rs7903146与饮食摄入之间的相互作用,这些因素可能导致沙特阿拉伯成年人的MetS。方法:这项横断面研究包括271名成年参与者(年龄在20-55岁 ),男女均有或没有超重或肥胖(体重指数在18-35 kg/m2之间)。使用食物频率问卷进行人体测量和饮食评估。采集空腹血样,分析血脂、葡萄糖和胰岛素水平。采用实时聚合酶链反应进行遗传分析。采用单因素回归分析TCF7L2 SNP rs7903146与实验室参数之间的关系,并检验SNP与饮食的相互作用。分析采用加性模型,其中T等位基因为效应等位基因。结果:SNP rs7903146与腰围(WC)存在显著相关性(p = 0.05)。TT基因型携带者WC最高(83.5 ±20.1  厘米),与CC基因型相比(80 ±14.2  厘米)和TC基因型(77.9 ±13.9  厘米)。苏格兰民族党rs7903146与总能量摄入量显著相关(p = 0.04)和饱和脂肪酸(SFA, = 0.005页)和TT运营商总能量和SFA消费最高(3606.9 ±1554.7  千卡, 66.8±52.0  g,分别)。SNP rs7903146与总能量摄入对胰岛素水平的影响之间只有一个接近显著的相互作用(p = 0.04),与CC(-2.4 ± 3.1)和TC(-4.7 ± 2.8)相比,TT基因型携带者在较低能量摄入时胰岛素值(-5.3 ± 3.5)下降更大。没有发现显著的相互作用。结论:本研究发现SNP rs7903146与总能量和SFA消耗之间存在显著相关性。TT载体增加了总能量和SFA的消耗。未来的研究需要使用更大的样本量来确认SNP rs7903146和饮食之间的显著相互作用,这些因素可能导致沙特人群中的MetS。
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来源期刊
Frontiers in Nutrition
Frontiers in Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.20
自引率
8.00%
发文量
2891
审稿时长
12 weeks
期刊介绍: No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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