Handgrip weakness and overall life satisfaction decline: derivation of cutoff values and analysis of sex differences in older Chinese adults.

IF 4 2区农林科学 Q2 NUTRITION & DIETETICS

Frontiers in Nutrition Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1537818

Liangyu Yin, Lan Zhong

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Abstract

Background and aims: Handgrip strength (HGS) is a cost-effective indicator of skeletal muscle function. However, the sex-specific association between HGS and life satisfaction decline among older Chinese adults remains largely unknown.

Methods: This observational, cross-sectional multicenter study included 3,649 older adults (age range: 60-101 years) from a nationally representative survey in China. Overall life satisfaction was determined using a life satisfaction score (LSS). Correlations between variables were examined using a Spearman's correlation analysis. Receiver operating characteristic (ROC) curves were utilized to determine the HGS cutoffs for predicting a decline in LSS. Restricted cubic spline (RCS) analysis and multivariate logistic regression were employed to investigate the associations between low HGS and LSS.

Results: This study included 1,762 women and 1,887 men (median age = 68.3 years). LSS decline was observed in 485 (13.3%) participants. HGS was positively correlated with LSS in both men and women (both P < 0.05). Individuals with low HGS were associated with a higher rate of LSS decline (16.2% vs. 10.8%, P < 0.001). RCS analysis demonstrated a linear-like association between HGS and life satisfaction in men (P < 0.001, P nonlinear = 0.099), but not in women (P = 0.110, P nonlinear = 0.329). ROC analysis revealed that the optimal HGS cutoff for indicating the presence of LSS was 27.5 kg for men and 22.3 kg for women. Multivariable analysis showed that participants with low HGS had higher odds of experiencing a decline in LSS [odds ratios (OR) = 1.509, 95% confidence interval (CI) = 1.218-1.867]. This association was observed only in men (OR = 1.871, 95% CI = 1.358-2.562, P < 0.001), while it was attenuated in women (OR = 1.281, 95% CI = 0.964-1.701, P = 0.087).

Conclusion: This study establishes sex-specific cutoffs of HGS for identifying a decline in LSS among older Chinese adults. Low HGS is positively associated with LSS decline among men in a linear-like manner, but not among women. These findings might facilitate the development of strategies to promote healthy aging.

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握力无力与总体生活满意度下降：中国老年人截断值的推导与性别差异分析。

背景与目的：握力（HGS）是骨骼肌功能的有效指标。然而，HGS与中国老年人生活满意度下降之间的性别特异性关联在很大程度上仍然未知。方法：这项观察性、横断面多中心研究包括来自中国全国代表性调查的3,649名老年人（年龄范围：60-101岁）。总体生活满意度采用生活满意度评分（LSS）来确定。使用Spearman相关分析检验变量之间的相关性。利用受试者工作特征（ROC）曲线确定预测LSS下降的HGS截止值。采用限制性三次样条（RCS）分析和多变量logistic回归研究低HGS与LSS之间的关系。结果：该研究包括1762名女性和1887名男性（中位年龄= 68.3岁）。485名（13.3%）参与者观察到LSS下降。男女HGS与LSS呈正相关（P < 0.05）。HGS较低的个体LSS下降率较高（16.2%比10.8%,P < 0.001）。RCS分析显示，男性的HGS与生活满意度呈线性相关（P < 0.001， P非线性= 0.099），而女性无线性相关（P = 0.110， P非线性= 0.329）。ROC分析显示，表明LSS存在的最佳HGS截止值为男性27.5 kg和女性22.3 kg。多变量分析显示，低HGS的参与者LSS下降的几率更高[比值比(OR) = 1.509, 95%可信区间(CI) = 1.218-1.867]。这种相关性仅在男性中观察到（OR = 1.871, 95% CI = 1.358-2.562, P < 0.001），而在女性中减弱（OR = 1.281, 95% CI = 0.964-1.701, P = 0.087）。结论：本研究建立了HGS的性别特异性截止点，以确定中国老年人LSS的下降。在男性中，低HGS与LSS下降呈线性正相关，但在女性中则不然。这些发现可能有助于制定促进健康老龄化的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

5.20

自引率

8.00%

发文量

2891

审稿时长

12 weeks

期刊介绍： No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.