In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation.

IF 5 2区 医学 Q1 OPHTHALMOLOGY
Le Chang, Fen Song, Shijia Qu, Huazheng Cao, Yanan Wu, Lulu Xu, Jing Wang, Ruirui Zhang, Chao Xue, Yan Wang
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引用次数: 0

Abstract

Purpose: The purpose of this study was to investigate the in vivo biomechanical properties of crystalline lens nucleus and cortex in adults with myopia, their potential influences, and the correlation between these properties and ocular accommodation.

Methods: The study included 195 right eyes of 195 participants, divided into 4 groups based on spherical equivalent: emmetropia (37 eyes), low myopia (41 eyes), moderate myopia (59 eyes), and high myopia (58 eyes). Participants underwent comprehensive ophthalmological examinations, including intraocular pressure, axial length, cycloplegic refraction, lens morphology, accommodation measurements, and Brillouin optical scanning of the lens. Additionally, demographic information, such as age and sex, was recorded. Normality tests were performed on the data using the Kolmogorov-Smirnov test. Between-group differences were examined using the Kruskal-Wallis test. Correlation and multiple regression analyses were conducted to analyze the factors associated with lens biomechanical properties and accommodation.

Results: The mean longitudinal modulus of the crystalline lens nucleus (LMN), anterior cortex (LMAC), and posterior cortex (LMPC) was 3.395 ± 0.027 GPa, 3.030 ± 0.066 GPa, and 2.990 ± 0.066 GPa, respectively, in adult myopia and 3.342 ± 0.024 GPa, 3.015 ± 0.0488 GPa, and 2.978 ± 0.049 GPa, respectively, in emmetropia. LMN was significantly higher in myopia (difference = 0.047, 95% confidence interval [CI] = 0.037 to 0.057, P < 0.001) and increased significantly with higher degrees of myopia (standardized β = -0.712, P < 0.001). No statistical differences in the LMAC or LMPC were observed between myopia and emmetropia. Lens densitometry on the centerline was the only lens parameter independently correlated with LMN (standardized β = -0.282, P < 0.01). Increased LMN in myopia was independently correlated with increased amplitude of accommodation (AMP) and decreased accommodative facility (AF; standardized β = 0.198, -0.237, all P < 0.05).

Conclusions: LMN was significantly higher in adult patients with myopia than in emmetropia and increased with increasing myopia. Increased LMN in myopia significantly correlated with decreased AF and increased AMP. High LMN may be an important biological alteration during the development of adult myopia, especially high myopia, providing new insights into myopia pathogenesis.

成人近视眼晶状体核和晶状体皮层的体内布里渊分析及其与调节的相关性。
目的:探讨成人近视眼晶状体核和晶状体皮层的体内生物力学特性及其潜在影响,以及这些特性与眼部调节的相关性。方法:选取195名受试者的195只右眼,根据球体等效度分为4组:远视(37只)、低近视(41只)、中度近视(59只)、高度近视(58只)。参与者接受了全面的眼科检查,包括眼压、眼轴长度、睫状体屈光、晶状体形态、调节测量和晶状体布里渊光学扫描。此外,还记录了年龄和性别等人口统计信息。使用Kolmogorov-Smirnov检验对数据进行正态性检验。组间差异采用Kruskal-Wallis检验。通过相关分析和多元回归分析,分析影响晶状体生物力学性能和调节的因素。结果:成人近视晶状体核(LMN)、前皮层(LMAC)和后皮层(LMPC)的平均纵向模量分别为3.395±0.027 GPa、3.030±0.066 GPa和2.990±0.066 GPa;远视晶状体核(LMN)、前皮层(LMAC)和后皮层(LMPC)的平均纵向模量分别为3.342±0.024 GPa、3.015±0.0488 GPa和2.978±0.049 GPa。近视患者LMN显著增高(差异为0.047,95%可信区间[CI] = 0.037 ~ 0.057, P < 0.001),且随着近视程度的升高,LMN显著增高(标准化β = -0.712, P < 0.001)。近视眼和远视的LMAC和LMPC无统计学差异。中心线晶状体密度是唯一与LMN独立相关的晶状体参数(标准化β = -0.282, P < 0.01)。近视眼LMN的增加与调节幅度(AMP)的增加和调节设施(AF)的降低独立相关;标准化β = 0.198, -0.237, P均< 0.05)。结论:成年近视患者LMN明显高于远视患者,且随近视程度的增加而增加。近视LMN升高与AF降低和AMP升高显著相关,高LMN可能是成人近视特别是高度近视发展过程中重要的生物学改变,为近视发病机制的研究提供了新的思路。
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来源期刊
CiteScore
6.90
自引率
4.50%
发文量
339
审稿时长
1 months
期刊介绍: Investigative Ophthalmology & Visual Science (IOVS), published as ready online, is a peer-reviewed academic journal of the Association for Research in Vision and Ophthalmology (ARVO). IOVS features original research, mostly pertaining to clinical and laboratory ophthalmology and vision research in general.
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