TastePeptides-Meta: A One-Stop Platform for Taste Peptides and Their Structural Derivatives, Including Taste Properties, Interactions, and Prediction Models

Abstract

Taste peptides have nutritional and sensory properties, and their structural derivatives show unique taste modulation effects. The increasing number of taste peptide candidates requires a fast and accurate screening methodology using advanced detection tools. Notably, existing platforms lack integrated bioinformatics solutions to provide accurate retrieval and prediction capabilities. In response to this need, TastePeptides-Meta is proposed, comprising 2,926 peptides entries, 975 peptide structural derivatives, and 954 synergistic (enhancing) data from 282, 109, and 103 peer-reviewed studies, respectively. It was equipped with corresponding machine learning-driven prediction modules and domain-specific analytical toolkits. As an online interactive platform, TastePeptides-Meta provides multiple interfaces that allow searching, downloading and predicting taste peptides. We believe that the public availability of TastePeptides-Meta and its implementation of standardized data schemas will accelerate mechanistic investigations in the field of taste peptides and the development of data-driven, interpretable models for predicting and exploring taste mechanisms. The TastePeptides-Meta platform can be accessed online at http://www.tastepeptides-meta.com/.