Junliang Jiang, Ge Chen, Yonggang Li, Qinggang Zhao, Zhong Chen
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引用次数: 0
Abstract
Background: Sarcopenia, the accelerated loss of muscle mass and function, is commonly associated with aging, especially in older adults. While low serum calcium has been linked to muscle loss in individuals over 50, its relationship with sarcopenia in younger adults (20-60 years) is unclear. This study examines this association using data from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018.
Methods: This population-based, cross-sectional study analyzed participants aged 20-60 from NHANES 2011-2018. Individuals with missing data were excluded. Sarcopenia was assessed using appendicular skeletal muscle (ASM) measured by dual-energy X-ray absorptiometry, defined by ASM/BMI or ASM/Weight. Multiple logistic regression and stratified analyses were used to explore the correlation between serum calcium levels and sarcopenia prevalence.
Results: Among 7,309 adults, 578 (7.91%) had sarcopenia by ASM/BMI and 1,363 (18.65%) by ASM/Weight. Higher serum calcium levels were significantly associated with a lower risk of sarcopenia (ASM/BMI: OR 0.07, 95% CI 0.02-0.20; ASM/Weight: OR 0.09, 95% CI 0.04-0.19). The trend was consistent across age, gender, education, poverty income ratio, and race, with some exceptions.
Conclusion: This study highlights a negative association between serum calcium and sarcopenia risk in young and middle-aged adults, suggesting that calcium interventions could be beneficial in preventing sarcopenia in this population. However, the cross-sectional design precludes any inference of causality, and further longitudinal studies are warranted to confirm these findings.
背景：肌肉减少症，肌肉质量和功能的加速损失，通常与衰老有关，特别是在老年人中。虽然低血钙与50岁以上个体的肌肉损失有关，但其与年轻人（20-60 岁）肌肉减少症的关系尚不清楚。本研究使用2011年至2018年国家健康与营养检查调查（NHANES）的数据来检验这种关联。方法：这项基于人群的横断面研究分析了NHANES 2011-2018中20-60岁的参与者。排除资料缺失的个体。采用双能x线骨密度仪测量阑尾骨骼肌（ASM）来评估肌肉减少症，以ASM/BMI或ASM/Weight来定义。采用多元logistic回归和分层分析探讨血清钙水平与肌少症患病率的相关性。结果：在7309名成年人中，578名（7.91%）的ASM/BMI和1363名（18.65%）的ASM/Weight患有肌肉减少症。较高的血钙水平与较低的肌肉减少症风险显著相关(ASM/BMI: OR 0.07, 95% CI 0.02-0.20；ASM/权重：OR 0.09, 95% CI 0.04-0.19)。这一趋势在年龄、性别、教育程度、贫困收入比、种族等各方面都是一致的，但也有一些例外。结论：本研究强调了青壮年血清钙与肌少症风险之间的负相关，提示钙干预可能有助于预防这一人群的肌少症。然而，横断面设计排除了任何因果关系的推断，进一步的纵向研究是有必要的，以证实这些发现。
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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