Immune restoration mechanism analysis of Akkermansia PROBIO in mice treated with cyclophosphamide through Re-balancing microbiota composition

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-03-28 DOI:10.1016/j.fbio.2025.106450

Junpeng Zhang , Xin Ma , Wenjiao Du , Guangqing Mu , Xiaomeng Wu

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Abstract

Currently, a variety of viruses are assaulting people's bodies, making it especially crucial to enhance immunity. Akkermansia, a potential next-generation probiotic, has been reported to keep human health. Akkermansia PROBIO is a safety stain obtained for improving gut flora health. This study aimed to investigate the protective effects of Akkermansia PROBIO against immunosuppression induced by cyclophosphamide in mice. The findings indicated that Akkermansia PROBIO has the potential to alleviate immune damage caused by cyclophosphamide by restoring cytokine levels and regulating the expression of Claudins-1, ZO-1, and Occludin. Importantly, Akkermansia PROBIO would keep intestinal health via re-balancing microbiota composition including increasing Lactobacillus levels and reducing Proteobacteria levels. Simultaneously, a more in-depth investigation was conducted to reveal important associations between various microbiomes and the levels of short-chain fatty acids, aiming to examine the immune restoration process linked to Akkermansia PROBIO. The findings indicate that Akkermansia PROBIO is vital in influencing the gut microbiome, thus aiding in broader immune defense. This research offers potential probiotic candidates for enhancing human immunity.

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目前，各种病毒正在侵袭人们的身体，因此增强免疫力尤为重要。据报道，Akkermansia 是一种潜在的下一代益生菌，可以保持人体健康。Akkermansia PROBIO 是一种用于改善肠道菌群健康的安全染色剂。这项研究旨在调查 Akkermansia PROBIO 对环磷酰胺诱导的小鼠免疫抑制的保护作用。研究结果表明，Akkermansia PROBIO 有可能通过恢复细胞因子水平、调节 Claudins-1、ZO-1 和 Occludin 的表达来减轻环磷酰胺引起的免疫损伤。重要的是，Akkermansia PROBIO 可通过重新平衡微生物群的组成，包括提高乳酸杆菌的水平和降低变形杆菌的水平，保持肠道健康。与此同时，我们还进行了一项更深入的调查，以揭示各种微生物群与短链脂肪酸水平之间的重要关联，目的是研究与Akkermansia PROBIO有关的免疫恢复过程。研究结果表明，Akkermansia PROBIO 对影响肠道微生物群至关重要，从而有助于更广泛的免疫防御。这项研究为增强人体免疫力提供了潜在的候选益生菌。

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.