Lemon-derived exosome-like nanovesicles: A promising avenue for drug delivery system and therapeutic applications in biomedical science

IF 4.8 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Bioscience Pub Date : 2025-03-28 DOI:10.1016/j.fbio.2025.106474

Mansi Khadilkar , Sanchit Arora , Rohan Chand Sahu , Satyavati Rawat , Dinesh Kumar , Ashish Kumar Agrawal

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引用次数: 0

Abstract

Extracellular vesicles (EVs) are naturally occurring, phospholipid bilayer-enclosed vesicles that offer high bioavailability and minimal invasiveness, making them promising candidates for disease treatment, drug delivery vectors, and effective biomarkers for disease detection and diagnosis. As researchers continue to discover and characterize EVs from various origins and biogenesis, their role in intercellular communication for diagnostic and therapeutic purposes becomes increasingly clear. Plant-derived exosome-like nanovesicles (PELNs) are of particular interest due to their compatibility, low toxicity, high bioavailability, ease of absorption, and inherent therapeutic activities. Among the diverse plant sources, lemons stand out for their high nutritional value and wealth of phytochemicals and bioactive components. Recently, there has been significant research into PELNs, focusing on their pharmacological properties and potential applications in drug delivery. This review centres on lemon-derived exosome-like nanovesicles (LELNs), exploring their extraction methods, biological and therapeutic potential, and applications as effective drug delivery systems. By highlighting these aspects, we aim to encourage further research into LELNs to uncover additional properties and potential biomedical applications.

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来源期刊

Food Bioscience Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

6.40

自引率

5.80%

发文量

671

审稿时长

27 days

期刊介绍： Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.