A Hybrid N-AHP-Based TOPSIS Decision Support Approach for Investigation of the Effect of Different Solvents on the Bioactive Properties, Anticancer, and Antimicrobial Activities of Aronia melanocarpa Extract

IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY
Gulsum Ucak Ozkaya
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引用次数: 0

Abstract

The aim of this study was to extract the bioactive components in Aronia melanocarpa L. fruit, commonly referred to as chokeberry, using various solvents (80% methanol + 1% formic acid, 80% ethanol, and 70% acetone) individually and to evaluate them through the Neutrosophic-Analytical Hierarchy Process (N-AHP)-based TOPSIS method. The ethanolic (EEA), methanolic (MEA), and acetone (AEA) extracts derived from Aronia fruit were analyzed for total phenolic, flavonoid, and anthocyanin contents, as well as antioxidant, antimicrobial, and cytotoxic activities. The EEA exhibited the highest overall anthocyanin content. The MEA exhibited the highest DPPH levels. The AEA exhibited the highest levels of total phenolic compounds, total flavonoid content, and CUPRAC values. The EEA, MEA, and AEA exhibited IC50 values of 11.65, 11.71, and 10.51 mg/mL against Caco-2 adenocarcinoma cells, respectively. EEA and MEA exhibited superior antimicrobial efficacy compared to AEA. According to the weights determined by N-AHP, the extraction with methanol was found to be the best extraction method according to the TOPSIS analysis results performed on real data. In other words, the extract with the lowest IC50 value and the highest antimicrobial activity was the one extracted with methanol. This study concluded that the N-AHP-based TOPSIS method is a significant multiple decision-making approach for evaluating plant extracts based on established criteria and is applicable to food and phytochemical sciences.

Abstract Image

基于混合n - ahp的TOPSIS决策支持方法研究不同溶剂对黑果野茅提取物生物活性、抗癌和抗菌活性的影响
本研究采用不同溶剂(80%甲醇+ 1%甲酸、80%乙醇和70%丙酮)分别提取野樱桃果实中的生物活性成分,并采用基于中性粒细胞层次分析法(N-AHP)的TOPSIS法对其进行评价。研究了野荆果乙醇(EEA)、甲醇(MEA)和丙酮(AEA)提取物的总酚、类黄酮和花青素含量,以及抗氧化、抗菌和细胞毒活性。EEA的总花青素含量最高。MEA的DPPH含量最高。其中总酚类化合物、总黄酮含量和CUPRAC含量最高。EEA、MEA和AEA对Caco-2腺癌细胞的IC50值分别为11.65、11.71和10.51 mg/mL。与AEA相比,EEA和MEA具有更好的抗菌效果。根据N-AHP确定的权重,根据对实际数据的TOPSIS分析结果,甲醇提取是最佳提取方法。也就是说,用甲醇提取的提取物IC50值最低,抗菌活性最高。本研究认为,基于n- ahp的TOPSIS方法是基于既定标准评价植物提取物的一种重要的多重决策方法,适用于食品和植物化学科学。
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来源期刊
Food Science & Nutrition
Food Science & Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
5.10%
发文量
434
审稿时长
24 weeks
期刊介绍: Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.
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